Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction.

CONCLUSION: The αIIb(R990W) KI mice developed macrothrombocytopenia, which was primarily attributed to impaired proplatelet formation. In addition, Homo KI mice showed marked downregulation in αIIbβ3 expression in platelets with severe impaired platelet function, similar to Glanzmann thrombasthenia.
PMID: 31691484 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - November 5, 2019 Category: Hematology Authors: Akuta K, Kiyomizu K, Kashiwagi H, Kunishima S, Nishiura N, Banno F, Kokame K, Hisashi K, Kanakura Y, Miyata T, Tomiyama Y Tags: J Thromb Haemost Source Type: research