Everolimus vs Mycophenolate Mofetil in Heart TransplantationEverolimus vs Mycophenolate Mofetil in Heart Transplantation

In an open-label, 24-month trial, 721 de novo heart transplant recipients were randomized to everolimus 1.5 mg or 3.0 mg with reduced-dose cyclosporine, or mycophenolate mofetil 3 g/day with standard-dose cyclosporine. American Journal of Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news

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Contributors : Fadi G Lakkis ; Khodor Abou-DayaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAbstract: Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. It is not known however whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously upon a second encounter. Here, we show that murine monocytes and macrophages acquire memory specific to MHC-I antigens and identify paired immunoglobulin-like receptors-A (PIR-A) as the MHC-I receptors necessary for the memory response. We...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
We read with great interest the article by Acuna et al1, titled “Pregnancy outcomes in women with cardiothoracic transplants: A Systematic review and meta-analysis.” The authors investigated pregnancies following thoracic transplants.1 They concluded that delayed mortality for thoracic transplant recipients remains high and that these pregnancies continue to be at risk for hypertensive disorders, graft rejection, preterm birth, and neonatal mortality.1
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
This study summarizes the findings of the youngest participants in two previous randomized controlled trials.MethodThis is a hypothesis-generating study reporting the main results from the youngest participants in two larger randomized controlled trials investigating the effect of high-intensity interval training (HIT). The article summarizes the main results from 28 young participants (
Source: BMC Sports Science, Medicine and Rehabilitation - Category: Sports Medicine Source Type: research
Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-...
Source: ScienceNOW - Category: Science Authors: Tags: Immunology reports Source Type: news
AbstractPurposeThe correlation between right hepatic vein (RHV) diameter and inferior RHV (IRHV) incidence and that between IRHV incidence and other clinical features remain unclear. We investigated factors correlated with IRHV incidence as well as provide a simple and reliable method for predicting IRHV presence preoperatively.MethodsWe obtained computed tomography (CT) imaging data of 1980 patients from the Department of Radiology, Qingdao Municipal Hospital, from July 1, 2016, to July 1, 2017. We excluded patients with heart disease, inferior vena cava (IVC) disease, history of liver surgery or trauma, space-occupying l...
Source: Surgical and Radiologic Anatomy - Category: Anatomy Source Type: research
ell N Abstract Heart transplantation is the standard of therapy for patients with end-stage heart disease. Since the first human-to-human heart transplantation, performed in 1967, advances in organ donation, surgical techniques, organ preservation, perioperative care, immunologic risk assessment, immunosuppression agents, monitoring of graft function and surveillance of long-term complications have drastically increased recipient survival. However, there are yet many challenges in the modern era of heart transplantation in which immunosuppression may play a key role for further advances in the field. A fine-tuning...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
This article outlines the practical details required to perform the technique in order to avoid hyperacute rejection. PMID: 32493108 [PubMed - as supplied by publisher]
Source: Perfusion - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Perfusion Source Type: research
ConclusionsAcute asymptomatic rejection is rare after the second post ‐transplant year. Obtaining surveillance studies beyond the second post‐transplant year is not cost‐effective.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Heart transplant patients are a vulnerable population. A new study suggests a high risk for death if these patients contract COVID-19, pointing to the need for increased precautions and vigilance.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news
AbstractPurpose of the ReviewAlthough still a relatively new technology, long-term left ventricular assist devices (LVADs) for management of advanced heart failure is rapidly increasing. Initially designed as a bridge to transplant, these invasive devices are increasingly used as a destination therapy, creating unique and long-term infection risks. The aim of this comprehensive review is to highlight current evidence about the prevention, diagnosis, and management of LVAD-specific infections.Recent FindingsThere are two recent, major societal guidelines (The International Society for Heart and Lung Transplantation, 2017, a...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
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