Emerging indications for hyperbaric oxygen
Purpose of review To identify and discuss emerging trends in the therapeutic use of hyperbaric oxygen. Recent findings There has been a maturing of the clinical evidence to support the treatment of sudden hearing loss, a wide range of problematic chronic wound states and the prevention and treatment of end-organ damage associated with diabetes mellitus. On the other hand, the controversy continues concerning the use of hyperbaric oxygen therapy (HBOT) to treat sequelae of mild traumatic brain injury. HBOT remains poorly understood by many medical practitioners despite more than 50 years of clinical practice. Pharmacological actions arise from increased pressures of oxygen in the blood and tissues. Most therapeutic mechanisms identified are not the simple result of the reoxygenation of hypoxic tissue, but specific effects on immunological and metabolic pathways by this highly reactive element. HBOT remains controversial despite biological plausibility and a solid clinical evidence base in several disease states. Summary Multiple proposals for new indications for HBOT continue to emerge. Although many of these will likely prove of limited clinical importance, some show significant promise. Responsible practitioners remain acutely aware of the need for high-quality clinical evidence before introducing emerging indications into routine practice.
CONCLUSION: All these results indicate that SQC is an effective preventive and protective drug on skeletal muscle of diabetic macrovasculopathy, and could alleviate skeletal muscle tissue damage through affecting biological functions related to cell death and cell adhesion. PMID: 32096754 [PubMed - as supplied by publisher]
Conditions: Hyperglycemia; Metformin; Type 2 Diabetes; Hyperlactatemia Intervention: Drug: Metformin Hydrochloride Sponsor: Kepler University Hospital Not yet recruiting
Condition: Type 2 Diabetes Mellitus Intervention: Drug: Trelagliptin Sponsor: Takeda Not yet recruiting
CONCLUSION: Albumin values were not associated with wound complications or need for reoperation in patients undergoing body contouring. Further research is warranted. PMID: 32097112 [PubMed - as supplied by publisher]
CONCLUSIONS: The mechanism underlying this phenomenon relates to a decrease in the inflammatory reaction and oxidative stress, as well as a decrease in leaky gut. Such reactions increase insulin sensitivity and reduce autoimmune responses. PMID: 32096204 [PubMed - in process]
CONCLUSIONS: The prevalence of AF in CS should be studied more precisely, both in a scientific way and at the individual patient's level. PMID: 32096188 [PubMed - in process]
CONCLUSIONS: MiR-30c-5p evidently inhibited HG-induced EMT and renal fibrogenesis by down-regulation JAK1 in DN, providing a promising therapeutic strategy for the treatment of DN. PMID: 32096183 [PubMed - in process]
WEDNESDAY, Feb. 26, 2020 -- Longer duration of lactation is associated with a lower risk for type 2 diabetes among women with a history of gestational diabetes mellitus (GDM), according to a study published online Feb. 10 in Diabetes Care. Sylvia H....
Conclusions: The results demonstrated a favorable effect or tendency of meditative movements to improve blood glucose and blood lipid levels in patients with type 2 diabetes mellitus. The special effects of meditative movements in type 2 diabetes mellitus patients need further research. PMID: 32089725 [PubMed]