FDA OKs First Rifabutin-Based H Pylori Therapy Talicia FDA OKs First Rifabutin-Based H Pylori Therapy Talicia

Talicia combines omeprazole, amoxicillin, and rifabutin and is designed to address growing bacterial resistance to standard clarithromycin-based H pylori therapy.FDA Approvals
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Alert Source Type: news

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Authors: Zhang F, Chen C, Hu J, Su R, Zhang J, Han Z, Chen H, Li Y Abstract Helicobacter pylori (H. pylori) is a gram-negative pathogen that colonizes gastric epithelial cells. The drug resistance rates of H. pylori have dramatically increased, causing persistent infections. Chronic infection by H. pylori is a critical cause of gastritis, peptic ulcers and even gastric cancer. In host cells, autophagy is stimulated to maintain cellular homeostasis following intracellular pathogen recognition by the innate immune defense system. However, H. pylori-induced autophagy is not consistent during acute and chronic infectio...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
AbstractThe Indian Society of Gastroenterology developed this evidence-based practice guideline for management of gastroesophageal reflux disease (GERD) in adults. A modified Delphi process was used to develop this consensus containing 58 statements, which were generated by electronic voting iteration as well as face-to-face meeting and review of the supporting literature primarily from India. These statements include 10 on epidemiology, 8 on clinical presentation, 10 on investigations, 23 on treatment (including medical, endoscopic, and surgical modalities), and 7 on complications of GERD. When the proportion of those who...
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
No abstract available
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
AbstractAnkylosing spondylitis (AS) and undifferentiated spondylarthritis (uSpA) are related inflammatory diseases affecting the spine and joints with infections among possible etiological factors.Helicobacter pylori(H. pylori) may affect the development of inflammatory diseases. Thus, we hypothesized thatH. pylori infection affects AS and uSpA development. This cohort study was performed in Denmark with 56,000 patients from primary health care centers who were enrolled when a UBT was performed. They were followed for a median time of 8  years. From nationwide administrative registries, we extracted personal, diagnost...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Serine protease HtrA exhibits both proteolytic and chaperone activities, which are involved in cellular protein quality control. Moreover, HtrA is an important virulence factor in many pathogens including Helicob...
Source: Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: Research Source Type: research
We have previously shown that Lactobacillus gasseri Kx110A1, a human stomach isolate, can colonize mouse stomach and reduce the initial colonization of Helicobacter pylori. Here, we investigated the role of sortase-dependent proteins (SDPs) involved in these functions by the construction of a mutant for srtA, the gene encoding the housekeeping sortase that covalently anchors SDPs to the cell surface. The srtA mutant showed a decrease in hydrophobicity and autoaggregation under acidic conditions, indicating the effect of SDPs on cell surface properties. Correspondingly, the srtA mutant lost the capacity to adhere to gastric...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions: This study suggests a synergistic interaction betweenH. pyloriinfection, especiallycagA-positiveH. pylori,andPro/Pro genotype ofTP53 codon 72 polymorphism might play a significant role in the pathogenesis of GC in the Vietnamese population.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
Conclusion: This first preliminary study advances our knowledge about the bacterial community ofH. dromedarii ticks and provides a basis for pathogen surveillance and studying the influences of symbionts on vector competence. Presence of pathogens in ticks, raise concerns about potential transmission of these agents to humans or animals.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
ABSTRACT BACKGROUND: Helicobacter pylori infection in Chile remains as a public and private health-care system ’ s challenge, with a prevalence of the infection over 70%. Nowadays, antibiotic treatment of the infection is mandatory to prevent the arising of severe associated diseases but failures in the eradication therapy mainly due to clarithromycin resistance has been observed worldwide and first line eradication therapy seems to be not effective anymore in several geographical areas. Thus, health-care systems are committed to maintain an epidemiological surveillance upon the evolution of the antibiotic resistance...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
ABSTRACT BACKGROUND: Helicobacter pylori infection is the most important risk factor for gastric atrophy and intestinal metaplasia, both considered gastric cancer precursor lesions. Therefore, the investigation of the occurrence of H. pylori infection, precursor lesions and associated factors guides the adoption of specific strategies for the control this type of cancer. OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients undergoing upper digestive endoscopy, as well as the prevalence of intestinal metaplasia, atrophy and chronic inflammation and their association with H. pylori infection. METHODS: A r...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
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