18F-Fluciclovine Parameters on Targeted Prostate Biopsy Associated with True Positivity in Recurrent Prostate Cancer

Conclusion: True positivity of 18F-fluciclovine–targeted prostate biopsy in non–prostatectomy-treated patients correlates with focal uptake, TBR (blood pool and marrow), and subjective highest suspicion level. A marrow TBR of 1.9 at the early time point and 1.8 at the delayed time point had optimal discriminating capabilities. Despite the relatively low intraprostate positive predictive value (34.0%) with 18F-fluciclovine, application of these parameters to interpretative criteria may improve true positivity in the treated prostate.

Source: Journal of Nuclear Medicine - October 31, 2019 Category: Nuclear Medicine Authors: Abiodun-Ojo, O. A., Akintayo, A. A., Akin-Akintayo, O. O., Tade, F. I., Nieh, P. T., Master, V. A., Alemozaffar, M., Osunkoya, A. O., Goodman, M. M., Fei, B., Schuster, D. M. Tags: Clinical Source Type: research