Handling founder inbreeding in forensic kinship analysis

We propose an extension of standard methods for computing pedigree likelihoods, in which pedigree founders are allowed to be inbred. Support for inbred founders is implemented in the forrel R package for forensic pedigree analysis. This enables for the first time background inbreeding to be modelled and studied in a variety of applications, including likelihood ratios, exclusion probabilities, relatedness inference and simulation studies. We illustrate these advances through two study cases.
Source: Forensic Science International: Genetics Supplement Series - Category: Forensic Medicine Authors: Source Type: research