Ion channels as potential redox sensors in lysosomes.

Ion channels as potential redox sensors in lysosomes. Channels (Austin). 2019 Dec;13(1):477-482 Authors: Yu J, Yang J Abstract Lysosomes are central organelles that recycle materials and energy to maintain intracellular homeostasis. Lysosomes are capable of sensing environmental cues such as nutrition to regulate their function accordingly. Whether lysosomes can sense redox signaling, however, was unclear. Here in this review, we summarized recent evidence of lysosomal ion channel as redox sensors for this organelle. We also discussed their roles in lysosomal diseases that features imbalanced redox. PMID: 31662029 [PubMed - in process]
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research