Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et  al

Cystic fibrosis related diabetes (CFRD) remains a frequent extra-pulmonary complication of cystic fibrosis (CF) – adding considerably to the treatment burden [1,2]. CFRD is primarily caused by insulin deficiency based on destruction of islet cells in the pancreas, although recent research suggests that CFTR in itself interferes with insulin secretion and glycaemic control [3,4]. Glucose metabolism impairmen t in CF starts from early infancy and continues during life with variable progression, primarily in pancreatic insufficient patients [5–7].

Source: Journal of Cystic Fibrosis - October 30, 2019 Category: Respiratory Medicine Authors: Hanne V Olesen, Pavel Drevinek, Vincent A Gulmans, Elpis Hatziagorou, Andreas Jung, Meir Mei-Zahav, Natasa Stojnic, Muriel Thomas, Anna Zolin, ECFSPR Steering Group Tags: Original Article Source Type: research