Cancers, Vol. 11, Pages 1687: Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury
Cancers, Vol. 11, Pages 1687: Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury
Cancers doi: 10.3390/cancers11111687
Authors:
Katrin Bankov
Claudia Döring
Adam Ustaszewski
Maciej Giefing
Marco Herling
Chiara Cencioni
Francesco Spallotta
Carlo Gaetano
Ralf Küppers
Martin-Leo Hansmann
Sylvia Hartmann
Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas in Western Europe. The nodular sclerosing subtype of cHL (NS cHL) is characterized by a proliferation of fibroblasts in the tumor microenvironment, leading to fibrotic bands surrounding the lymphoma infiltrate. Several studies have described a crosstalk between the tumour cells of cHL, the Hodgkin- and Reed-Sternberg (HRS) cells, and cancer-associated fibroblasts. However, to date a deep molecular characterization of these fibroblasts is lacking. Thus, the aim of the present study is a comprehensive characterization of these fibroblasts. Gene expression profiling and methylation profiles of fibroblasts isolated from primary lymph node suspensions revealed persistent differences between fibroblasts obtained from NS cHL and lymphadenitis. NS cHL derived fibroblasts exhibit a myofibroblastic phenotype characterized by myocardin (MYOCD) expression. Moreover, TIMP3, an inhibitor of matrix metalloproteinases, was strongly upregulated in NS cHL fibroblasts, likely contribu...
Source: Cancers - Category: Cancer & Oncology Authors: Katrin Bankov Claudia D öring Adam Ustaszewski Maciej Giefing Marco Herling Chiara Cencioni Francesco Spallotta Carlo Gaetano Ralf K üppers Martin-Leo Hansmann Sylvia Hartmann Tags: Article Source Type: research