Notch initiates AV shunts from capillaries [Medical Sciences]

Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanisms that underlie AVM formation remain poorly understood. Here,...

Source: Proceedings of the National Academy of Sciences - December 16, 2014 Category: Science Authors: Murphy, P. A., Kim, T. N., Huang, L., Nielsen, C. M., Lawton, M. T., Adams, R. H., Schaffer, C. B., Wang, R. A. Tags: Biological Sciences Source Type: research