Preliminary exploration of a novel method for the deconvolution of DNA mixtures by pyrosequencing
In this study, we propose a novel method for the analysis of DNA mixtures. This method employed multiplex pyrosequencing to sequence several selected microhaplotypes. Employing a sparse representation-based AdvISER-MH-PYRO algorithm, the original pyrosequencing (PSQ) signals of the DNA mixtures were deciphered to determine the contributors of the mixtures.
Source: Forensic Science International: Genetics Supplement Series - Category: Forensic Medicine Authors: Yueyan Cao, Qiuyue Wang, Qiang Zhu, Yuguo Huang, Yuhan Hu, Yijun Zhou, Yufang Wang, Ji Zhang Source Type: research