No evidence of tachyphylaxis for insulinotropic actions of Glucose-Dependent Insulinotropic Polypeptide (GIP) in subjects with type 2 diabetes, their first-degree relatives, or in healthy subjects

ConclusionsRapid tachyphylaxis in response to continuous exposure to slightly supraphysiological concentrations of GIP does not explain the reduced insulinotropic response to GIP infusions in patients with type 2 diabetes or their first-degree relatives.
Source: Peptides - Category: Biochemistry Source Type: research