Human leukocyte antigens class II in CIDP spectrum neuropathies

CIDP spectrum encompasses several clinical variants and the reasons of the heterogeneous clinical expression and the variable response to therapy are scarcely known.HLA associations are common in dysimmune conditions. In CIDP, few studies reported no associations or HLA-DR13/DQ6 association in some populations but, to date, a clear confirmed association is lacking.We analyzed expression of HLA-DR and DQ haplotypes in 24 CIDP patients and 216 healthy subject.HLA-DR3 and DR3/DQ2 were significantly more frequent in CIDP patients than in the control group.

Source: Journal of the Neurological Sciences - October 22, 2019 Category: Neurology Authors: Stefano Cotti Piccinelli, Graziella Carella, Micol Frassi, Filomena Caria, Serena Gallo Cassarino, Enrico Baldelli, Mirella Marini, Angela Tincani, Alessandro Padovani, Massimiliano Filosto Source Type: research