Bernard Fisher, Pioneer in Breast Cancer Research, Dies at 101 Bernard Fisher, Pioneer in Breast Cancer Research, Dies at 101

His research brought an end to radical mastectomy, and he pioneered the design and implementation of large-scale multi-institutional randomized clinical trials.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

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AbstractBackgroundNeoadjuvant chemotherapy (NAC) for breast cancer increases breast-conserving surgery (BCS) rates, but many women opt for mastectomy with contralateral prophylactic mastectomy (CPM). Here we evaluate factors associated with CPM use in women undergoing mastectomy post-NAC.MethodsA retrospective institutional NAC database review identified women with clinical stage I-III, unilateral invasive breast cancer undergoing unilateral mastectomy (UM) or CPM mastectomy from 9/2013 to 12/2017. Clinical/pathologic characteristics, imaging, and presence of contraindications to BCS post-NAC were compared, with subset ana...
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewInflammatory breast cancer (IBC) is an aggressive type of breast cancer with poor prognosis. Treatment for non-metastatic disease is neoadjuvant chemotherapy followed by mastectomy and radiation. IBC diagnosis is primarily a clinical diagnosis, which can lead to misdiagnosis and delayed management. In addition, there are no molecular criteria for diagnosis or therapeutic regimens developed specifically for IBC. We aimed to discuss recent developments in IBC, including diagnosis, molecular mechanisms, and treatment.Recent FindingsRecently, the Union for International Cancer Control (UICC) and the Am...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
ConclusionsThere were no OS differences in patients undergoing MAST, XRT, or MXRT, suggesting breast conservation can be considered in patients with OBC.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
This study aims to determine if a disparity in BR utilization exists in women from Appalachia Kentucky. Methods A retrospective, population-based cohort study was conducted from January 1, 2006, to December 31, 2015. The Kentucky Cancer Registry was queried to identify population-level data for female patients diagnosed with breast cancer and treated with mastectomy. A multivariate logistic regression model controlling for patient, disease, and treatment characteristics was constructed to predict the likelihood of BR. Results Bivariate testing showed differences (P
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research
AbstractPancytopenia is a rare complication among patients with breast cancer. Here, we report a case of pancytopenia due to massive bone marrow carcinomatosis (BMC) developed after local radiotherapy following to mastectomy. A 48-year-old woman with locally advanced breast cancer underwent mastectomy and axillary lymph node dissection. During adjuvant chemotherapy, rapidly growing supraclavicular lymph node metastasis was noted, so chemotherapy was discontinued and local radiotherapy was performed. There was no myelosuppression or systemic metastases prior to radiotherapy, but 2 weeks after the completion of radiotherapy,...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
Tara Huck, 34, had a mastectomy after her mother, aunt and grandmother were all diagnosed with breast cancer. Doctors believed an unidentified faulty gene could be responsible.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The rate of breast-conserving surgery (BCS) is low in China. Many patients choose mastectomy even when informed that there is no difference in the overall survival rate compared with that of BCS plus radiother...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
We present, 5-year follow-up of QOL scores in breast cancer patients from India.MethodsWe interviewed women undergoing breast cancer surgery preoperatively, at 6  months after surgery, and at 1 year and 5 years, postoperatively. QOL scores were evaluated using FACT B questionnaire. Average QOL scores of women undergoing BCT were compared with those undergoing MRM. Total scores, domain scores and trends of scores over time were analyzed.ResultsWe interviewed 54 women with a mean age of 53  years (SD 9 ± years). QOL scores in all the women, dipped during the treatment period, in a...
Source: Quality of Life Research - Category: Health Management Source Type: research
PRECISE: Occult breast cancer presents a clinical challenge for clinicians. Using propensity score matching, we found no difference in overall survival among mastectomy alone, radiation alone, or mastectomy and radiation.
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
After a Styles column about one woman ’s experience with an early diagnosis, readers shared poignant stories of fear and survival.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Breast Cancer Mastectomy Radiation Mammography Tamoxifen (Drug) New York Times Source Type: news
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