Novel protein synthesis –breakdown complexes: TASCCed with fibrosis after G2-M arrest

Although mild acute kidney injury (AKI) commonly encountered in clinical practice may resolve completely, it is increasingly apparent from human and animal data that more severe AKI often progresses to chronic kidney disease (CKD).1 After kidney injury, tubular epithelial cells (TECs) are primarily responsible for regeneration and repair by proliferating, de-differentiating, migrating, and redifferentiating.2 Depending on the extent of injury, additional repair may occur through fibrosis, the replacement of nonviable kidney tissue by the extracellular matrix.

Source: Kidney International - October 21, 2019 Category: Urology & Nephrology Authors: Madhav C. Menon, Niralee Patel, John Cijiang He Tags: Nephrology Digest Source Type: research