Zona incerta deep-brain stimulation in orthostatic tremor: efficacy and mechanism of improvement

ConclusionsBilateral caudal zona incerta deep-brain stimulation is effective in refractory orthostatic tremor. Two independent central oscillations were found at tremor and double tremor frequency. Zona incerta DBS produces improvement in OT patients possibly by modifying the abnormal oscillatory proprioceptive input from leg muscles. Frequent changes in deep-brain stimulation settings were required for maintaining the clinical benefit.
Source: Journal of Neurology - Category: Neurology Source Type: research