LEA 4. Tibial Occlusive Disease in Chronic Kidney Disease: Saving the Limb and the Kidney

The incidence of chronic kidney disease (CKD) has reached pandemic proportions across the world. Critical limb ischemia (CLI) in the CKD patient is a huge clinical challenge often culminating in major amputation or mortality. Endovascular revascularization is sometimes not feasible because of potential contrast agent-induced damage to the residual renal function, whereas heavy calcification may limit the success of such interventions. Surgical revascularization in these patients also carries added challenges and risks with seemingly poor outcomes in terms of limb salvage.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research

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Obesity is one of the major pandemics of the 21st century. In 2013 –2014, the prevalence of obesity in the US was>35% among men and 40% among women [1]. The World Health Organization (WHO) reported that 39% of men and 39% of women were overweight, and 11% of men and 15% of women were obese in 2016. Thus, approximately 2 billion adults worldwide were overweight and, among them, more than half a billion were obese [2]. Obesity is a chronic disease adversely affecting the quality of life and is associated with many comorbidities, like hypertension, dyslipidemia, type 2 diabetes (T2DM), cardiovascular disease (CVD), n...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
This study examined influenza vaccination in patients with SCD as a potential marker of quality of care delivery. The study population included black individuals aged 1 to =1 diagnosis of stroke, TIA or epilepsy/recurrent seizures); cardio pulmonary complications (>=1 diagnosis of chronic pulmonary heart disease, pulmonary hypertension, malaise and fatigue, edema, chest pain or hypoxemia); kidney disease (>=1 diagnosis of chronic kidney disease/renal failure, proteinuria), avascular necrosis or ulcer of lower limbs (adapted from Afenyi-Annan, 2008, Candrilli. 2011, Elmariah. 2014). A total of 1544 patients with SCD w...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster II Source Type: research
The incidence of chronic kidney disease (CKD) has reached pandemic proportions across the world. Occlusive arterial disease causing critical limb ischemia and sepsis in the CKD patient is a huge clinical challenge often culminating in major amputation or mortality. Successful revascularization of these patients is challenging with added limitations due to impaired renal function, difficulties in contrast-enhanced imaging, heavily calcified arteries, and overall comorbid status.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Type 2 Diabetes Mellitus (T2DM) has emerged as a global pandemic in recent times [1] and is the tenth most common cause of deaths in South-East Asia [2]. Uncontrolled long-term hyperglycemia due to DM predisposes to acute and chronic vascular complications leading to ischemic heart disease, cerebrovascular disease and chronic kidney disease (CKD) in the form of ‘End stage of renal diseases (ESRD)’ in both the developed and developing countries [3]. The prevalence of CKD as a diabetic microvascular complication (diabetic nephropathy) is quite high in South-East Asia [4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Type 2 Diabetes Mellitus (T2DM) has emerged as a global pandemic in recent times [1] and is the tenth most common cause of death in South East Asia [2]. Uncontrolled long-term hyperglycemia due to DM predisposes to acute and chronic vascular complications leading to ischemic heart disease, cerebrovascular disease and chronic kidney disease (CKD) in the form of ‘End stage of renal diseases (ESRD)’ in both the developed and developing countries [3]. The prevalence of CKD as a diabetic microvascular complication (diabetic nephropathy) is quite high in South East Asia [4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Abstract Obesity is an emerging pandemic driven by consumption of a diet rich in high fat and high refined carbohydrates (western diet [WD]) and a sedentary life style in both children and adults. There is mounting evidence that arterial stiffness in obesity is an independent and strong predictor of adverse cardiovascular disease (CVD), cognitive functional decline and chronic kidney disease. Cardiovascular stiffness is a precursor to systolic hypertension, cardiac diastolic dysfunction, impairment of coronary and cerebral blood flow, and atherosclerosis. Moreover, premenopausal women lose the CVD protection norma...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
Conclusion: Diabetes and chronic kidney disease due to diabetes, as well as high fasting plasma glucose in general, currently constitute a major and growing public health problem in Brazil. Actions to date for their prevention and control have been slow considering the magnitude of this burden.RESUMO: Introdu ção e objetivo: O projeto Global Burden of Disease (GBD) 2015 estendeu suas análises para incluir unidades federativas brasileiras de maneira separada. Aproveitamos os avanços metodológicos do GBD para descrever a carga atual de diabetes e hiperglicemia no Brasil. Métodos: Uti...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Abstract Japan has the highest proportion of older people in the world, 25.9% of the population were aged 65 or above in 2014. Although there have been no populationā€based studies that precisely examined the prevalence of heart failure in Japan, one report estimated the number of Japanese outpatients with left ventricular dysfunction was 979, 000 (0.8% of total population), which was projected to increase gradually as the population ages, reaching 1.3 million by 2030. Ischemic etiology was less frequently observed in Japan (31–47%) than in western population (54–57%). The prevalence of HF with preserved eject...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Editorial Source Type: research
Diabetic nephropathy is a major complication of diabetes mellitus and is the largest single and leading cause of end stage renal disease (ESRD) in the developed world [1,2]. In 2009, the incidence of ESRD in Taiwan was the third highest in the world and its prevalence was the highest [3]. Individuals with chronic kidney disease (CKD) have a prevalence of diabetes four times higher than those without CKD [4]. In addition, in Asia, a high prevalence of proteinuria (up to 60%) has been reported in type 2 diabetes, which suggests an impending pandemic of renal and cardiovascular diseases in this region [5].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
The prevalence of diabetes is increasing and has already reached pandemic proportions. Diabetes is a well-known risk factor for chronic kidney disease. Diabetic kidney disease (DKD) occurs in up to 40% of people with type 1 or 2 diabetes and is nowadays the leading cause of end-stage renal disease (ESRD). Among several factors involved in the development and progression of DKD are also inflammation and oxidative stress. Unfortunately, there is a paucity of sensitive and specific biomarkers for the early prediction of patients who will develop DKD or will progress to ESRD. This review summarizes the evidence regarding the p...
Source: Nephron - Category: Urology & Nephrology Source Type: research
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