Comparative in vitro activity of bacteriophage endolysin HY-133 against Staphylococcus aureus attached to vascular graft surface

AbstractNovel strategies are needed for combatingStaphylococcus aureus biofilm in vascular graft infections. We investigated the in vitro activity of bacteriophage endolysin HY-133, daptomycin and rifampin againstS. aureus attached to vascular graft surface. Daptomycin showed rapid bactericidal effect on surface-associatedS. aureus, while the activity of HY-133 on graft surface-adherent cells was moderate and rifampin did not achieve bactericidal effect. Even in the highest concentrations, all antimicrobials used failed in a complete eradication of the surface-adherent bacteria.
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research