Macrophages promote DNA repair of double strand break in multiple myeloma cells by non-homologous end joining(NHEJ), nevertheless sacrifice the accuracy of NHEJ

Multiple myeloma (MM) is a hematological malignancy of B cells, characterized by clonal proliferation of malignant plasma cells. DNA damage and genomic instability play an important role in the pathogenesis of MM. Based on the characteristics of high heterogeneity and genomic instability of MM, and the protective effect of M Φs on MM cells (MMCs), our study intended to further clarify whether MΦs affect MMCs DNA damage response and DNA repair, and the relationship between MΦs and genomic instability of MMCs.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: zhen cai, Mengmeng Dong, Jingsong He, Xiaoyan Han, Donghua He, Gaofeng Zheng, Wenjun Wu, Yi Zhao, Yang Yang, He Huang, Xi Huang, Enfan Zhang, Yi Li, Li Yang Source Type: research