The impact of response kinetics following initial therapy for multiple myeloma in the era of novel agents

Rapid remission has long been recognized as an important predictor for long-time survival in acute leukemia (AL). However, the effects of response kinetics on survival seems to be different from those in AL. A rapid reduction of tumor burden probably indicates a chemotherapy-sensitive population. But on the other hand, a high proliferative activity of plasma cell may be responsible for the rapid response. The effects of response kinetics on outcome for MM remain largely unexplored. Method: The relationship between response kinetics and outcome were prospectively assessed in 626 patients with newly diagnosed MM that were included in a prospective, non-randomized clinical trial (BDH 2008/02).

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: yuting Yan, xuehan Mao, Liu Jiahui, Fan huishou, lizengjun zengjun, Chenxing Du, mu hao, Lugui Qiu, gang An Source Type: research