Development, characterization and in vitro toxicity evaluation of nanoemulsion-loaded hydrogel based on copaiba oil and coenzyme Q10

Publication date: Available online 16 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Fiammetta Nigro, Cristal Cerqueir, André Rossi, Verônica Cardoso, Alane Beatriz Vermelho, Eduardo Ricci-Júnior, Elisabete P. dos Santos, Claudia Regina E. MansurAbstractCoenzyme Q10 (CQ10) is a lipophilic substance synthesized endogenously by the body that has antioxidant, photoprotective and wound-healing properties. However, when applied exogenously in topical preparations, there are obstacles to its permeation through the stratum corneum due to its high molar mass, low water solubility and susceptibility to photodegradation. In this case, permeation is desired for the substance to attain high levels of bioavailability in the lower levels of the epidermis, protecting keratinocytes against oxidative damages, and in the dermis to stimulate the proliferation of fibroblasts and collagen. In this work, we used copaiba oil, a vegetable oil with properties similar to those of CQ10, to compose oil-in-water (O/W) nanoemulsions with CQ10 (NECQ10) and without it (NECO), for comparative purposes, prepared by ultrasound processing. After adding the thickener ammonium acryloyldimethyltaurate/VP copolymer to the NECQ10 and NECO, the formulations NECQ10 g and NECOg, respectively, were evaluated regarding the particle size distribution, which was monomodal with mean droplet size of about 60 nm and had mean polydispersity index...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research

Related Links:

CONCLUSION: technical success, treatment success, procedure duration, and overall adverse event rate were comparable between ERCP-BD and EUS-BD in decompressing malignant distal biliary obstruction. Nevertheless, EUS-BD had a significantly lower rate of PEP and a lower tendency toward stent reintervention than ERCP-BD. Therefore, EUS-BD might be a suitable alternative to ERCP-BD when performed by experts. PMID: 31729233 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
We examined US sensitivity for diagnosis of HCC in obese patients. Methods: Liver transplant patients data with HCC in explant was used (January 2012-December 2017). All patients underwent liver US within 3 months of diagnosis of HCC. Number/size of HCC lesions were extracted from radiologic and pathologic reports. Obesity was defined as BMI ≥30 kg/m2. Results: One hundred sixteen patients were included. 80% were male, with mean BMI of 31 kg/m2. The most common underlying liver disease was hepatitis C virus (62%). At the time of diagnosis, median number of HCC lesions was 2 (interquartile range [IQR], 1-3), and ...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Publication date: Available online 16 November 2019Source: Food ChemistryAuthor(s): Wenjun Zhao, Qing Shu, Guoqing He, Chen QiheAbstractThis work investigated the reduction of bovine whey proteins antigenicity by ultrasonic pretreatment and microbial fermentation. Firstly, bovine whey proteins was pretreated by ultrasonic techniques, and its secondary structure was detected by circular dichroism. The pretreated whey proteins was used as the fermentation substrate by Kluyveromyces marxianus for microbial transformation. The single factor design and Box-Behnken Design (BBD) were carried out with the aim to optimize culture t...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: 25 December 2019Source: Journal of Industrial and Engineering Chemistry, Volume 80Author(s): Seyed Hossein Mansourian, Shahrokh Shahhosseini, Ali MalekiAbstractThe possibility of using ultrasound irradiation to enhance a model fuel desulfurization process has been investigated in this work. For this reason, oxidative desulfurization (ODS) and ultrasound assisted oxidative desulfurization (UAOD) processes were applied, using oxygen, as the only oxidative agent, and polyoxometalate (POM) catalysts. The catalysts were analyzed using FT-IR, XRD, EDX, SEM and N2 adsorption–desorption isotherms along with...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Conclusion: Simulations demonstrate the feasibility of endobronchial ultrasound applicators to deliver thermal coagulation of 2-3 cm diameter tumors adjacent to or accessible from major and deep lung airways. PMID: 31726895 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Publication date: Available online 15 November 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Zhipan Wei, Bangtian Peng, Yulin Bai, Zaiqiang Wu, Yanwei Zhang, Feng Ai, Wanli GaoAbstractBoth cardiac myxomas and papillary fibroelastomas are primary benign cardiac tumors, but it is very rare for tumors with different histologies to occur in different valves of the same heart. A 5-month-old infant underwent resection of a mitral valve mass + mitral valvuloplasty at our hospital. The tricuspid valve mass was still small, and no tricuspid regurgitation was observed; therefore, the tricuspid valve mass ...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
This article will review the imaging features of common benign and malignant conditions of the female urethra including diverticula, benign cystic and solid lesions, malignancy, surgical slings, and injection of bulking agents.
Source: Abdominal Imaging - Category: Radiology Source Type: research
Over the past 3 decades, significant improvements and innovations have occurred in the field of diagnostic and therapeutic endoscopy. For example, the availability of high-definition endoscopes with detailed image enhancement capabilities allows us to routinely seek out nonpolypoid and precancerous lesions within the gastrointestinal tract; the wide variety of user-friendly accessories allows us to perform more complex resections through the endoscope, and advancements with endoscopic ultrasound allows us to perform precise assessments and therapies.
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Tags: Preface Source Type: research
Conclusions: Motor and cognitive skills decay at different times for pleural and cardiac images. Future ultrasound curricula should retrain skills at a maximum of 8 weeks from initial training. They should focus more on didactic sessions related to image identification for pleural images, and more hands-on image acquisition training for cardiac images, which represents a novel finding.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
Publication date: Available online 25 October 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Lori-Ann Oliver, Jodi-Ann Oliver, Sargis Ohanyan, William Park, Aharon Benelyahoo, Nalini VadiveluPeripheral venous access is perhaps the most commonly performed procedure in hospitals, urgent care, or surgical centers across the country. The ability to obtain peripheral intravenous (IV) access, and in a timely manner, is arguably one of the most important skill sets to be mastered by health care professionals. While skill and experience play a role in successful and timely vascular access, numerous pati...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
More News: Antidoxidants | Chemistry | Nanotechnology | Toxicology | Ultrasound | Vegetables