Development, characterization and in vitro toxicity evaluation of nanoemulsion-loaded hydrogel based on copaiba oil and coenzyme Q10

Publication date: Available online 16 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Fiammetta Nigro, Cristal Cerqueir, André Rossi, Verônica Cardoso, Alane Beatriz Vermelho, Eduardo Ricci-Júnior, Elisabete P. dos Santos, Claudia Regina E. MansurAbstractCoenzyme Q10 (CQ10) is a lipophilic substance synthesized endogenously by the body that has antioxidant, photoprotective and wound-healing properties. However, when applied exogenously in topical preparations, there are obstacles to its permeation through the stratum corneum due to its high molar mass, low water solubility and susceptibility to photodegradation. In this case, permeation is desired for the substance to attain high levels of bioavailability in the lower levels of the epidermis, protecting keratinocytes against oxidative damages, and in the dermis to stimulate the proliferation of fibroblasts and collagen. In this work, we used copaiba oil, a vegetable oil with properties similar to those of CQ10, to compose oil-in-water (O/W) nanoemulsions with CQ10 (NECQ10) and without it (NECO), for comparative purposes, prepared by ultrasound processing. After adding the thickener ammonium acryloyldimethyltaurate/VP copolymer to the NECQ10 and NECO, the formulations NECQ10 g and NECOg, respectively, were evaluated regarding the particle size distribution, which was monomodal with mean droplet size of about 60 nm and had mean polydispersity index (PDI) of 0.2. Furthermore,...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research