Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer

ConclusionsmTOR signaling is highly activated in TNBC tumors. As single rapalog treatment is insufficient to block mTOR signaling in rapalog-resistant TNBC cells, our results thus provide a potential multi-kinase inhibitor combinatorial strategy to overcome mTOR-targeted therapy resistance in TNBC cells.

http://link.springer.com/10.1007/s10549-019-05380-z

Source: Breast Cancer Research and Treatment - October 17, 2019 Category: Cancer & Oncology Source Type: research