Molecular interactions during Borrelia burgdorferi migration from the vector to the mammalian nervous system.

CONCLUSION: Different specific molecules of the vector, pathogen and host result in LNB establishment. After B. burgdorferi species penetrate host skin through a tick bite, they are confronted by the immune defenses of the host. However, they are helped by specific proteins in different interactions, and the disease is established. The interactions between the vector, pathogen and host are shown in Table 1 and Figure 1. Knowledge of these molecular interactions can aid development of therapeutics against LNB and LD. Others: We systematically describe the different molecular tick-pathogen-host interactions. PMID: 31613726 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31613726?dopt=Abstract

Source: Current Protein and Peptide Science - October 14, 2019 Category: Biochemistry Authors: Esso Abi M, Ji Z, Jian M, Dai X, Bai R, Ding Z, Luo L, Chen T, Wang F, Wen S, Zhou G, Bao F, Liu A Tags: Curr Protein Pept Sci Source Type: research