Preparation of Injectable Egg Albumin Based Composite Implant for Photothermal Therapy of Tumor.

Preparation of Injectable Egg Albumin Based Composite Implant for Photothermal Therapy of Tumor. Chembiochem. 2019 Oct 15;: Authors: Zhang J, An X, Zheng Y, Chen Y, Wu C, Wang S Abstract Polymeric hydrogels featured with three dimensional network structure have found tremendous applications in biomedicine. Herein, we report the synthesis of egg albumin (EA) based multifunctional implant as a carrier that capable of synergistically delivering photothermal transducing agent (poly dopamine, PDA) to tumor. The formation of PDA was achieved by utilizing the basicity of EA, while the formation of hydrogel implant was realized by the in vitro/in vivo near-infrared (NIR) laser induced hyperthermia of PDA. The as-prepared PDA@EA implant exhibits high photothermal conversion efficiency (38.7%). After being implanted in vivo, the EA based implant shows great versatility in the treatment of malignant tumor. Furthermore, chemotherapeutics (doxorubicin, DOX) and contrast agent (iohexol) that were dispersed in the EA solution in advance can also be firmly entrapped in the hydrogel along with the hydrogel formation. Without showing obvious toxicity to healthy tissue, the multifunctional EA-based implant is anticipated to act a promising system for synergistic cancer treatment. PMID: 31613042 [PubMed - as supplied by publisher]
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research