Molecules, Vol. 24, Pages 3713: Essential Oils and Their Natural Active Compounds Presenting Antifungal Properties

Molecules, Vol. 24, Pages 3713: Essential Oils and Their Natural Active Compounds Presenting Antifungal Properties Molecules doi: 10.3390/molecules24203713 Authors: D’agostino Tesse Frippiat Machouart Debourgogne The current rise in invasive fungal infections due to the increase in immunosuppressive therapies is a real concern. Moreover, the emergence of resistant strains induces therapeutic failures. In light of these issues, new classes of antifungals are anticipated. Therefore, the plant kingdom represents an immense potential of natural resources to exploit for these purposes. The aim of this review is to provide information about the antifungal effect of some important essential oils, and to describe the advances made in determining the mechanism of action more precisely. Finally, the issues of toxicity and resistance of fungi to essential oils will be discussed.
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research

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AbstractBackground Echinocandins are well-established agents for the treatment of patients with fungal infections, but growing evidence questions their safety in special patient populations prone to systemic inflammatory responses.Objective The study aimed to analyse early hemodynamic changes during echinocandin therapy in critically ill surgical patients.Setting The study was conducted at the surgical intensive care unit at the University Hospital of Giessen, Germany.Methods This single-centre retrospective study includes data from critically ill patients who underwent primary antifungal treatment during 2009 –2013....
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite the progress in drug development, the occurrence of microbial resistance is still a significant concern. Alternative therapeutic strategies are required for non-responding or relapsing patients. Chimeric antigen receptor (CAR) T cells has revolutionized cancer immunotherapy, providing a potential therapeutic option for patients who are unresponsive to standard treatments. Recently two CAR T cell therapies, Yescarta® (Kite Pharma/Gilead) and Kymriah® (Novartis) were approved by the FDA for the treatments of certain types ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, a stable topical delivery system for efinaconazole (EFN) was designed to enhance absorption potential through the skin and nail plate by incorporating ethanol, diethylene glycol monoethyl ether (Transcutol P) and isopropyl myristate, and cyclomethicone into the topical solution as a delivery vehicle, permeation enhancers, and a wetting agent, respectively. In addition, the stability of EFN in the formulation was significantly improved by adding butylated hydroxytoluene, diethylenetriamine pentaacetic acid, and citric acid as an antioxidant, chelating agent, and pH-adjusting agent, respectively, without disco...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
AbstractRezafungin acetate is a novel echinocandin in clinical development for prevention and treatment of invasive fungal infections. Rezafungin is differentiated by a pharmacokinetic/pharmacodynamic (PK/PD) profile that includes a long half ‐life allowing once‐weekly administration, front‐loaded plasma drug exposures associated with antifungal efficacy, and penetration into deep‐seated infections, such as intra‐abdominal abscesses. In this series of in vivo studies, rezafungin demonstrated efficacy in the treatment of neutrop enic mouse models of disseminated candidiasis, including infection caused by azole‐r...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: Oral antifungal therapies are effective, but significant adverse effects limit their use. Although topical antifungal therapies have minimal adverse events, they are less effective than oral antifungal therapies, due to poor nail penetration. Therefore, there is a need for exploring more effective and/or alternative treatment modalities for the treatment of onychomycosis which are safer and more effective. PMID: 31738146 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
(Indiana University) Indiana University researchers have identified how two immune receptors coordinate closely to trigger a powerful response against fungal invaders, which could help advance research on cancer therapies.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractPurpose of ReviewWe have created a general review of the disease in this article, especially of the clinical features, diagnosis, new treatments and preventive measures.SummaryCongenital cutaneous candidiasis is a vertically transmitted fungal infection which affects term and premature newborn. It is considered as an underdiagnosed pathology, and infection caused byCandida albicans is considered the most common aetiology.Recent FindingsClinically characterized by erythematous papular lesions and pustules with collarette scale. It can also affect other organs and systems by causing an invasive fungal infection. Diag...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
This article summarizes the main epidemiological characteristics of tinea gladiatorum, new outbreaks that have been presented over the years, and theories about their transmission, diagnosis, treatment, and prophylactic measures.Recent FindingsDespite the controversy, recent studies defined that the transmission of tinea gladiatorum is by skin-to-skin contact and through fomites. Once the infection is acquired, it is difficult to control due to its rapid dissemination to other wrestlers, so great importance has been taken to prevention.SummaryDespite dermatophytosis still being considered as one of the major public health ...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
AbstractPurpose of the ReviewCandida albicans vulvovaginitis is one of the most frequent symptomatic infections in women and its incidence increases in reproductive age and pregnancy. Currently there are more specific and sensitive tests to identifyCandida species that are resistant to antifungal agents, such as PCR and MALDI TOF MS, in order to improve prognosis.Recent FindingsThe genusCandida is part of the microbiota in humans; however, many species can become pathogenic. Vulvovaginitis caused by non-albicansCandida are becoming very important due to their high levels of antifungal resistance, which makes treatment diff...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewFungal infections account for significant morbidity and mortality in HIV-infected children particularly in developing countries where there is lack of skilled personnel and infrastructure to make the appropriate diagnosis. This is further compounded by poor availability and accessibility of the antifungals needed to treat these infections. The purpose of this review is to highlight the paucity of data on AIDS-related mycoses in the paediatric age group and make appropriate recommendations to address challenges associated with mycoses in this population.Recent FindingsThese infections are categorise...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
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