Nano-carbon and titanium clip combined labeling assisted surgery before neoadjuvant radiotherapy and chemotherapy for rectal cancer.

Nano-carbon and titanium clip combined labeling assisted surgery before neoadjuvant radiotherapy and chemotherapy for rectal cancer. Asian J Surg. 2019 Oct 10;: Authors: Yu C, Lin N, Yang J, Wang Y PMID: 31607418 [PubMed - as supplied by publisher]
Source: Asian Journal of Surgery - Category: Surgery Authors: Tags: Asian J Surg Source Type: research

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ConclusionThis study has demonstrated delaying a patient to adjuvant ChT will lower their DFS and increase their HR compared with those whose treatment is not delayed. We have long been too focused on local control; hence, priority needs to be shifted to efforts in managing potential distant disease in a timely manner.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
ConclusionR2-resections do not result in a survival benefit compared to non-surgical treatment in this non-randomized series. Patients with a high chance on a R2-resection could be offered non-surgical treatment, without local resection.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
AbstractPurposeTo evaluate the role of diffusion kurtosis and diffusivity as potential imaging biomarkers to predict response to neoadjuvant chemoradiation therapy (CRT) from baseline staging magnetic resonance imaging (MRI) in locally advanced rectal cancer (LARC).Materials and methodsThis retrospective study included 45 consecutive patients (31 male/14 female) who underwent baseline MRI with highb-value sequences (up to 1500  mm/s2) for LARC followed by neoadjuvant chemoradiation and surgical resection. The mean age was 57.4  years (range 34.2–72.9). An abdominal radiologist using open source software man...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Conclusion: The SIB-VMAT technique is effective and safe for irradiating locally advanced rectal cancer. Its effectiveness is expressed in higher clinical and pathological complete response rates and safety with the same rates of acute toxicity. PMID: 31651118 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conditions:   Rectal Neoplasms Malignant;   Rectum Carcinoma;   Rectal Cancer Interventions:   Drug: Capecitabine;   Drug: Oxaliplatin;   Radiation: Radiotherapy;   Procedure: Rectal cancer surgery Sponsor:   Blokhin's Russian Cancer Research Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Extending the waiting period by 4 weeks following RCT has no influence on the oncological outcomes of T3/T4 rectal cancers.
Source: Annals of Surgery - Category: Surgery Tags: ESA-RANDOMIZED CONTROLLED TRIALS Source Type: research
Authors: Kye BH, Lee SH, Jeong WK, Yu CS, Park IJ, Kim HR, Kim J, Lee IK, Park KJ, Choi HJ, Kim HY, Baek JH, Lee YS Abstract Purpose: The optimal treatment for synchronous liver metastasis (LM) from colorectal cancer (CRC) depends on various factors. The present study was intended to investigate the oncologic outcome according to the time of resection of metastatic lesions. Methods: Data from patients who underwent treatment with curative intent for primary CRC and synchronous LM between 2004 and 2009 from 9 university hospitals in Korea were collected retrospectively. One hundred forty-three patients underwent...
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
We examined the association between pathological lateral pelvic lymph node (LPLN) metastasis and the LPLN diameter in patients with locally advanced rectal cancer (LARC) who received a neoadjuvant chemotherapy (NAC) regimen based on oxaliplatin as induction chemotherapy. We aimed to determine whether or not the LPLN size predicts LPLN metastasis in NAC cases.MethodsWe retrospectively examined data from 3 institutes for 60 patients with LARC who received mesorectal excision and LPLN dissection after NAC. We evaluated the LPLN size on magnetic resonance imaging (MRI) scans acquired before and after NAC. We performed multivar...
Source: Surgery Today - Category: Surgery Source Type: research
"Watch and Wait" for complete clinical response after neoadjuvant chemoradiotherapy for rectal cancer. Minerva Chir. 2019 Sep 30;: Authors: Peacock O, Chang GJ Abstract The management of rectal cancer has evolved substantially over recent decades, becoming increasingly complex. This was once a disease associated with high mortality and limited treatment options that typically necessitated a permanent colostomy, has now become a model for multidisciplinary evaluation, treatment and surgical advancement. Despite advances in the rates of total mesorectal excision, decreased local recurrence and ...
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
In vitro and in vivo studies on the association of long non‑coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5‑fluorouracil in rectal cancer. Int J Oncol. 2019 Oct 04;: Authors: Yokoyama Y, Sakatani T, Wada R, Ishino K, Kudo M, Koizumi M, Yamada T, Yoshida H, Naito Z Abstract There is no predictive biomarker for response to 5‑fluorouracil (5FU)‑based neoadjuvant chemotherapy (NAC) in rectal cancer. In the present study, we examined potential long non‑coding RNAs (lncRNAs) linked to the susceptibility to 5FU in cultured colorectal cancer cells, and in bi...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
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