Fragment-based screening with natural products for novel anti-parasitic disease drug discovery

Volume 14, Issue 12, December 2019, Page 1283-1295 .
Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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Conclusion: Mite populations with reduced susceptibility to permethrin exist in Austria and necessitate the evaluation of alternative treatment regimens.Key MessagesHuman scabies is a rising major public health issue worldwide and has been designated as a neglected tropical disease by the World Health Organization.Resistance to permethrin, the most widely prescribed first-line therapy for scabies is to date underreported.At present, treatment recommendations remain controversially discussed as official guidelines do not address current development of resistances, and therefore their clinical applicability is limited. P...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
[VOA] The challenges faced by African nations during the coronavirus pandemic are about much more than a rapidly spreading virus, American aid officials say. They're concerned about the threats it poses to proper nutrition, the economy, liberties and freedoms, and the ongoing war against a deadly parasite that has plagued this continent for centuries: malaria.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Warming events are increasing in magnitude and severity, threatening ecosystems More at This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04101
Source: Journal of the American Chemical Society - Category: Chemistry Authors: Source Type: research
Authors: Meregildo ED Abstract Neurocysticercosis (NCC) is a global health problem. In more developed countries, NCC is mainly a disease affecting immigrants. In developing countries, NCC is the most common parasitic disease of the nervous system and the main cause of acquired epilepsy. NCC is also an unrecognized cause of strokes and could account for 4%-12% of strokes. Here, I report a case of a 58-year-old woman who presented to the emergency department (ED) with severe headache, vomiting, and sudden loss of consciousness. Multiple NCC and Fisher grade 4 aneurysmal subarachnoid hemorrhage (SAH) were demonstrated...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
BackgroundMalaria is a major public health concern in Togo. The Est-Mono district of Togo has a population of 150,000. Accordingly, the Guangzhou University of Chinese Medicine, China and the Ministry of Health and Social Security, Togo launched a nationwide Mass Drug Administration Project with artemisinin–piperaquine (AP) in Est-Mono. Before launching this project, the sensitivity test of AP was conducted in a general clinic in Elawagnon, Togo. With this background, we evaluated the efficacy and safety of AP for the treatment of uncomplicated falciparum malaria in children under the age of 5 years.MethodsChildren a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Cellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around humans. The horizon on cell division variants is expanded here by advancing insights on the fascinating cell division modes found in the Apicomplexa, a key group of protozoan parasites. The Apicomplexa display remarkable variation in offspring number, whether karyokinesis follows each S/M-phase or not, and whether daughter cells bud in the cytoplasm or bud from the cortex. We find that the terminology used to describe the various manifestations of asexual apicomplexan cel...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Trypanosoma cruzi P21 protein (P21) is a putative secreted and immunomodulatory molecule with potent bioactive properties such as induction of phagocytosis and actin cytoskeleton polymerization. Despite the bioactive properties described so far, the action of P21 on parasite replication in muscle cell lineage or T. cruzi parasitism during acute experimental infection is unclear. We observed that recombinant P21 (rP21) decreased the multiplication of T. cruzi in C2C12 myoblasts, phenomenon associated with greater actin polymerization and IFN-γ and IL-4 higher expression. During experimental infection, lower cardiac ne...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 3 June 2020Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): R.A. Butler, R.T. Trout Fryxell, A.E. Houston, E.K. Bowers, D. Paulsen, L.B. Coons, M.L. Kennedy
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
Authors: Ondriska F, Boldiš V, Stanislavová M, Antolová D, Miterpáková M, Hanáček A, Vešperová S, Jančovič I Abstract Dirofilaria repens is the causative agent of human subcutaneous or, less often, ocular dirofilariasis. The work presents a rare case of ocular dirofilariasis manifested by previous subcutaneous migration accompanied by severe headache symptoms. In February 2017, a 58-yr-old man from Trnava region, western Slovakia, noticed red and itchy stripes on his left leg. Inflamed but painless stripes disappeared and showed up again every 5-7 days, mig...
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
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