Assigning confidence to molecular property prediction
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 15, 2021 Category: Drugs & Pharmacology Authors: AkshatKumar Nigam Robert Pollice Matthew F. D. Hurley Riley J. Hickman Matteo Aldeghi Naruki Yoshikawa Seyone Chithrananda Vincent A. Voelz Al án Aspuru-Guzik Source Type: research

Advantages and disadvantages of mouse models of chronic lymphocytic leukemia in drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 11, 2021 Category: Drugs & Pharmacology Authors: Heribert Playa-Albinyana Fabian Arenas Dolors Colomer Source Type: research

Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 10, 2021 Category: Drugs & Pharmacology Authors: Paul Richardson Source Type: research

How can we accelerate COVID-19 vaccine discovery?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 9, 2021 Category: Drugs & Pharmacology Authors: Giulia Russo Valentina Di Salvatore Filippo Caraci Cristina Curreli Marco Viceconti Francesco Pappalardo Source Type: research

Computational representations of protein –ligand interfaces for structure-based virtual screening
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 4, 2021 Category: Drugs & Pharmacology Authors: Tong Qin Zihao Zhu Xiang Simon Wang Jie Xia Song Wu Source Type: research

Artificial intelligence in early drug discovery enabling precision medicine
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 2, 2021 Category: Drugs & Pharmacology Authors: Fabio Boniolo Emilio Dorigatti Alexander J. Ohnmacht Dieter Saur Benjamin Schubert Michael P. Menden Source Type: research

Understanding collagen interactions and their targeted regulation by novel drugs
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 1, 2021 Category: Drugs & Pharmacology Authors: Marialucia Gallorini Simone Carradori Source Type: research

The machine learning life cycle and the cloud: implications for drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 31, 2021 Category: Drugs & Pharmacology Authors: Ola Spjuth Jens Frid Andreas Hellander Source Type: research

Current directions in combining simulation-based macromolecular modeling approaches with deep learning
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 31, 2021 Category: Drugs & Pharmacology Authors: Vikram Khipple Mulligan Source Type: research

Approaches for refining and furthering the development of CAR-based T cell therapies for solid malignancies
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 26, 2021 Category: Drugs & Pharmacology Authors: Caroline M Hull John Maher Source Type: research

Advances in venom peptide drug discovery: where are we at and where are we heading?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 24, 2021 Category: Drugs & Pharmacology Authors: Taylor B. Smallwood Richard J. Clark Source Type: research

An overview of ProTide technology and its implications to drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 24, 2021 Category: Drugs & Pharmacology Authors: Michaela Serpi Fabrizio Pertusati Source Type: research

Advances in the discovery of novel agents for the treatment of glaucoma
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 18, 2021 Category: Drugs & Pharmacology Authors: Francesco Mincione Alessio Nocentini Claudiu T. Supuran Source Type: research

Machine learning techniques applied to the drug design and discovery of new antivirals: a brief look over the past decade
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 7, 2021 Category: Drugs & Pharmacology Authors: Mateus S á Magalhães Serafim Valtair Severino dos Santos J únior Jadson Castro Gertrudes Vin ícius Gonçalves Maltarollo Kathia Maria Honorio Source Type: research

The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - May 5, 2021 Category: Drugs & Pharmacology Authors: Stefano Fiorucci Michele Biagioli Monia Baldoni Patrizia Ricci Valentina Sepe Angela Zampella Eleonora Distrutti Source Type: research

1,2,3,4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 28, 2021 Category: Drugs & Pharmacology Authors: Faheem Banoth Karan Kumar Kondapalli Venkata Gowri Chandra Sekhar Subhash Chander Selvaraj Kunjiappan Sankaranarayanan Murugesan Source Type: research

Using 3D in vitro cell culture models in anti-cancer drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 26, 2021 Category: Drugs & Pharmacology Authors: Sigrid A Langhans Source Type: research

Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 23, 2021 Category: Drugs & Pharmacology Authors: Carmen Gil Ana Martinez Source Type: research

Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 21, 2021 Category: Drugs & Pharmacology Authors: Geetika Garg Abhishek Kumar Singh Sandeep Singh Syed Ibrahim Rizvi Source Type: research

Critical assessment of AI in drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 19, 2021 Category: Drugs & Pharmacology Authors: W. Patrick Walters Regina Barzilay Source Type: research

Is PROTAC technology really a game changer for central nervous system drug discovery?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 19, 2021 Category: Drugs & Pharmacology Authors: Kayla Farrell Timothy J. Jarome Source Type: research

Discovery of CFTR modulators for the treatment of cystic fibrosis
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 13, 2021 Category: Drugs & Pharmacology Authors: Miqu éias Lopes-Pacheco Nicoletta Pedemonte Guido Veit Source Type: research

Knowledge graphs and their applications in drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 12, 2021 Category: Drugs & Pharmacology Authors: Finlay MacLean Source Type: research

Analysis of the SARS-CoV-2-host protein interaction network reveals new biology and drug candidates: focus on the spike surface glycoprotein and RNA polymerase
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 7, 2021 Category: Drugs & Pharmacology Authors: Esen Sokullu Maxime Pinard Marie-Soleil Gauthier Benoit Coulombe Source Type: research

Artificial intelligence in drug discovery: recent advances and future perspectives
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - April 2, 2021 Category: Drugs & Pharmacology Authors: Jos é Jiménez-Luna Francesca Grisoni Nils Weskamp Gisbert Schneider Source Type: research

What makes a good fragment in fragment-based drug discovery?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 26, 2021 Category: Drugs & Pharmacology Authors: Zenon Konteatis Source Type: research

Drugging multiple same-allele driver mutations in cancer
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 26, 2021 Category: Drugs & Pharmacology Authors: Ruth Nussinov Mingzhen Zhang Ryan Maloney Hyunbum Jang Source Type: research

The challenges of generalizability in artificial intelligence for ADME/Tox endpoint and activity prediction
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 19, 2021 Category: Drugs & Pharmacology Authors: David Z Huang J. Christian Baber Sogole Sami Bahmanyar Source Type: research

Evolution of assay interference concepts in drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 18, 2021 Category: Drugs & Pharmacology Authors: J ürgen Bajorath Source Type: research

Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 15, 2021 Category: Drugs & Pharmacology Authors: Xuan Huang Xiaoyong Zhang Mengji Lu Source Type: research

Ligand efficiency indices for effective drug discovery: a unifying vector formulation
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 11, 2021 Category: Drugs & Pharmacology Authors: Celerino Abad-Zapatero Source Type: research

Tackling the reproducibility problem to empower translation of preclinical academic drug discovery: is there an answer?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 5, 2021 Category: Drugs & Pharmacology Authors: David R. Janero Source Type: research

Accelerating Alzheimer ’s disease drug discovery and development: what’s the way forward?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 3, 2021 Category: Drugs & Pharmacology Authors: Bruno P. Imbimbo Stefania Ippati Mark Watling Claudia Balducci Source Type: research

Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - March 2, 2021 Category: Drugs & Pharmacology Authors: Hidayat Hussain Iftikhar Ali Daijie Wang Faruck L. Hakkim Bernhard Westermann Luay Rashan Ishtiaq Ahmed Ivan R. Green Source Type: research

Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - February 25, 2021 Category: Drugs & Pharmacology Authors: Josep M. Sierra Miguel Vi ñas Source Type: research

Practical constraints with machine learning in drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - February 19, 2021 Category: Drugs & Pharmacology Authors: Igor I. Baskin Source Type: research

Artificial intelligence, machine learning, and drug repurposing in cancer
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - February 12, 2021 Category: Drugs & Pharmacology Authors: Ziaurrehman Tanoli Markus V ähä-Koskela Tero Aittokallio Source Type: research

Novel approaches to glycomimetic design: development of small molecular weight lectin antagonists
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - February 5, 2021 Category: Drugs & Pharmacology Authors: Vishnu C. Damalanka Amarendar Reddy Maddirala James W. Janetka Source Type: research

Harnessing the power of foot-and-mouth-disease virus for targeting integrin alpha-v beta-6 for the therapy of cancer
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - February 3, 2021 Category: Drugs & Pharmacology Authors: Amelia Meecham John Marshall Source Type: research

An update on the emerging approaches for histone deacetylase (HDAC) inhibitor drug discovery and future perspectives
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - February 3, 2021 Category: Drugs & Pharmacology Authors: Ma Su Xingyu Gong Feng Liu Source Type: research

Drug discovery through the isolation of natural products from Burkholderia
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 29, 2021 Category: Drugs & Pharmacology Authors: Adam Foxfire Andrew Riley Buhrow Ravi S. Orugunty Leif Smith Source Type: research

From leptin to lasers: the past and present of mouse models of obesity
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 29, 2021 Category: Drugs & Pharmacology Authors: Joshua R. Barton Adam E. Snook Scott A. Waldman Source Type: research

Innovative screening models for the discovery of new schizophrenia drug therapies: an integrated approach
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 29, 2021 Category: Drugs & Pharmacology Authors: Marinos G. Sotiropoulos Eleni Poulogiannopoulou Foteini Delis Christina Dalla Katerina Antoniou Nikolaos Kokras Source Type: research

Preclinical discovery and development of abemaciclib used to treat breast cancer
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 12, 2021 Category: Drugs & Pharmacology Authors: Matthew D. Wright Md, Jame Abraham Source Type: research

Recent advances in quantitative structure –activity relationship models of antimalarial drugs
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 11, 2021 Category: Drugs & Pharmacology Authors: Probir Kumar Ojha Vinay Kumar Joyita Roy Kunal Roy Source Type: research

Current strategies for the discovery and bioconjugation of smaller, targetable drug conjugates tailored for solid tumor therapy
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 11, 2021 Category: Drugs & Pharmacology Authors: Mahendra P. Deonarain Gokhan Yahioglu Source Type: research

The discovery and development of IP3 receptor modulators: an update
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 6, 2021 Category: Drugs & Pharmacology Authors: Jessica Gambardella Marco B. Morelli Xujun Wang Vanessa Castellanos Pasquale Mone Gaetano Santulli Source Type: research

CRISPRing future medicines
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - January 4, 2021 Category: Drugs & Pharmacology Authors: Laure Grand Moursel Mijke Visser Geraldine Servant Selvi Durmus Anne-Marie Zuurmond Source Type: research

Have molecular hybrids delivered effective anti-cancer treatments and what should future drug discovery focus on?
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - December 31, 2020 Category: Drugs & Pharmacology Authors: Shalini Vipan Kumar Source Type: research

Mouse models for mesothelioma drug discovery and development
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - December 31, 2020 Category: Drugs & Pharmacology Authors: Kenneth P. Seastedt Nathanael Pruett Chuong D. Hoang Source Type: research