First Glimpse of Epigenetic Effects on Pemphigus  Foliaceus

Pemphigus foliaceus (PF) is an autoimmune disease, sporadic across the globe, but endemic in Brazil. A significant portion of PF autoantibodies target desmosomal glycoproteins, especially desmoglein-1, which are associated with the occurrence of painful blisters in the granular skin layer (Spindler et  al., 2007). Epigenetic mechanisms have been implicated in autoimmune skin diseases. Among them, dysregulated DNA and histone methylation contribute to systemic lupus erythematosus (Hung et al., 2018), psoriasis (Manczinger and Kemény, 2013), pemphigus vulgaris (Zhao et al., 2012a), and alopecia areata (Zhao et al., 2012b).

Source: Journal of Investigative Dermatology - July 30, 2019 Category: Dermatology Authors: Mariana Basso Spadoni, Val éria Bumiller-Bini, Maria Luiza Petzl-Erler, Danillo Gardenal Augusto, Angelica Beate Winter Boldt Tags: Letters to the Editor Source Type: research