Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling and atrial arrhythmia

Atrial fibrillation (AF) is the most common type of arrhythmia. Abnormal atrial myocyte Ca2+ handling promotes aberrant membrane excitability and remodeling important for atrial arrhythmogenesis. The sequence of molecular events leading to loss of normal atrial myocyte Ca2+ homeostasis is not established. Late Na+ current (INa,L) is increased in atrial myocytes from AF patients together with an increase in activity of Ca2+/calmodulin-dependent kinase II (CaMKII).

Source: Heart Rhythm - October 13, 2019 Category: Cardiology Authors: Amara Greer-Short, Hassan Musa, Katherina M. Alsina, Li Ni, Tarah A. Word, Julia O. Reynolds, Daniel Gratz, Cemantha Lane, Mona El-Refaey, Sathya Unudurthi, Michel Skaf, Ning Li, Vadim V. Fedorov, Xander H.T. Wehrens, Peter J. Mohler, Thomas J. Hund Source Type: research