Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (...

Source: Clinical Epigenetics - October 12, 2019 Category: Research Authors: Sylvain Garciaz, Lia N ’guyen Dasi, Pascal Finetti, Christine Chevalier, Julien Vernerey, Mathilde Poplineau, Nadine Platet, Stéphane Audebert, Matthieu Pophillat, Luc Camoin, François Bertucci, Boris Calmels, Christian Récher, Daniel Birnbaum, Chris Tags: Research Source Type: research