The Myth of Mycotoxins and Mold Injury

AbstractIn recent years, mold has been blamed for many symptoms or a constellation of symptoms. These symptoms are usually vague and subjective and difficult or impossible to measure or quantify. Moreover, there is no scientific evidence that mold has anything to do with these symptoms. In particular, the concept of toxic mold syndrome has permeated the public consciousness, and mycotoxins have falsely been associated with autoimmune diseases and a variety of other conditions. In fact, there is no evidence that the presence of mycotoxins in the air is enough to cause any disease known to man. Molds legitimately can cause allergies and can be a trigger for asthma. Certain specific molds such asAspergillus can be a cause of hypersensitivity pneumonitis. In immunocompromised hosts, both dermatologic and systemic infections can result from various fungi and can be associated with significant morbidity or even mortality. However, the existence of toxic mold syndrome has been disproven, despite the numerous disreputable practices such as testing homes for mold spores, measuring “mycotoxins” in the urine, and testing patients for IgG to mold. In truth, none of these techniques have been validated, nor do they have any relevance to any clinical disease. All that these tests that are being performed by laboratories of disrepute does is to further propagate misinformation and inflict unnecessary and often exorbitant costs on patients desperate for a clinical diagnosis, righ...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research

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Abstract Sex hormones are best known for their influences on reproduction, but they also have profound influences on the immune response. Examples of sex-specific differences include: (i) the relatively poor control of influenza virus infections in males compared to females, (ii) allergic asthma, an IgE-associated hypersensitivity reaction that is exacerbated in adolescent females compared to males, and (iii) systemic lupus erythematosus, a life-threatening autoimmune disease with a 9:1 female:male bias. Here we consider how estrogen and estrogen receptor α (ERα) may influence the immune response by mo...
Source: Cellular Immunology - Category: Allergy & Immunology Authors: Tags: Cell Immunol Source Type: research
Publication date: Available online 30 October 2019Source: Genes &DiseasesAuthor(s): Wei Wang, Tianhao Yao, Tianyi Zhang, Meiying Quan, Changyan Wang, Chen Wang, Lejia Zhang, Xiaoyan Tang, Shan Jian, Hongmei SongAbstractSelective immunoglobulin A deficiency (SIgAD) is considered to be the most common human primary immune-deficiency disease in the world. However, the incidence in China is obviously lower than Caucasian races. The definitionof SIgAD has changed over time with the progress of people's understanding. The scientific community did not reach a consensus on the definition until 1999. As a result, many previousl...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
We describe a case in which whole exome sequencing (WES) in a patient with CVID and associated lung disease revealed a new option for therapy.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Antiphospholipid syndrome is an autoimmune disease, genetic predisposition and exaggerated immunological response to viral and bacterial exposures have been postulated as possible etiology. To our knowledge, very few studies have described food-induced allergy association with the antiphospholipid syndrome.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Sj ögren's syndrome is an autoimmune disease characterized primarily by decreased exocrine gland function leading to eye and mouth dryness. Extraglandular manifestations occur less frequently.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Acquired angioedema (AAE) is a rare disorder characterized by recurrent episodes of swelling without hives and C1 esterase inhibitor deficiency. Although clinically it presents similarly to hereditary angioedema, AAE generally develops in older patients and is associated with underlying disease, most notably lymphoproliferative disorders and autoimmune conditions.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Thyroid acropachy is an extreme manifestation of the hypothyroid phase of autoimmune thyroid disease.2 Presenting symptoms include swelling of the digits and digital clubbing with periosteal reaction of the extremity bone. The chronological sequence begins with thyroid dysfunction, followed by ophthalmopathy, then dermopathy, and finally, myxedema manifesting as acropachy.2,3 The exact etiology is unknown although recent research points to interaction of TSH receptor in fibroblasts with TSH receptor antibodies, with fibroblast differentiation and proliferation and synthesis of Glycosaminoglycans which results in retention ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
As the review in this issue of the Annals makes clear, patients with common variable immunodeficiency (CVID) may exhibit one or more of a multiplicity of autoimmune diatheses involving any body system.1 The association of primary immunodeficiency diseases (PIDD) and autoimmunity is not restricted, however, to CVID.2 Similar associations between immunodeficiency and malignancy have been extensively reported as well.3 Our immunodeficiency patients are not merely subject to an increased incidence of the entire spectrum of common and exotic infections but to a panoply of life-threatening conditions that exceed the capacity of ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
Conclusions: Our study confirms that CD and PWAG share comorbidities of autoimmune nature. PWAG had more autoimmune/allergy-related disorders that may be associated with non-celiac gluten sensitivity a self-justifiable reason to be on the diet.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
ConclusionAs new data arise, revisions might soon be needed allowing AIT in the cases of patients treated with ACE inhibitors and beta-blockers, in elderly patients and in patients with concomitant autoimmune diseases and neoplasias in remission. The decision to prescribe AIT is always tailor-made, balancing risk vs benefit. Creating globally accepted guidelines would help Allergologists in their decision making.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
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