Cell-Specific Regulatory Effects of CXCR2 on Cholestatic Liver Injury.

In conclusion, neutrophil CXCR2 guides the cell to the site of injury, while CXCR2 on liver cells affects liver damage independent of neutrophil accumulation. CXCR2 appears to be a viable therapeutic target for cholestatic liver injury. PMID: 31604030 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31604030?dopt=Abstract

Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 10, 2019 Category: Physiology Authors: Konishi T, Schuster RM, Goetzman HS, Caldwell CC, Lentsch AB Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research