Incorporation of Biologic Response Variance Modeling Into the Clinic: Limiting Risk of Brachial Plexopathy and Other Late Effects of Breast Cancer Proton Beam Therapy

ConclusionsInstitution of a BP biologic dose constraint may reduce brachial plexopathy risk without compromising target coverage. MCBD plan evaluation provides valuable information to physicians that may assist in making clinical judgments regarding relative priority of target coverage versus normal tissue sparing.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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The primary purpose of this study was to investigate the impact of an air gap (AG) on breast cancer plans that are generated using the intensity-modulated proton therapy technique.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Research Article Source Type: research
In conclusion, this numerical study suggests that the ionoacoustic wave field may well be used to monitor the proton dose distribution during breast cancer treatment. PMID: 31600743 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
ConclusionsInstitution of a BP biological dose constraint may reduce brachial plexopathy risk without compromising target coverage. MCBD plan evaluation provides valuable information to physicians which may assist in making clinical judgments regarding relative priority of target coverage vs. normal tissue sparing.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
To investigate the role of intensity-modulated proton therapy (IMPT) for regional nodal irradiation in patients with breast carcinoma in comparison with volumetric-modulated arc therapy (VMAT).
Source: Clinical Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSION: If MC is more accurate than PB as reported in the literature, dosimetric and radiobiological results from the current study suggest that PB overestimates the target dose, EUD, and TCP for IMPT breast cancer treatment. The overestimation of dosimetric and radiobiological results of the target volume by PB needs to be further interpreted in terms of clinical outcome. PMID: 31343826 [PubMed - as supplied by publisher]
Source: Journal of Applied Clinical Medical Physics - Category: Physics Authors: Tags: J Appl Clin Med Phys Source Type: research
This article discusses its uses, effectiveness, and procedure.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Breast Cancer Source Type: news
The management of breast cancer requires multi-disciplinary collaboration in order to optimize oncologic outcomes and quality of life. Administration of post-mastectomy radiotherapy (PMRT) is indicated for some patients treated with mastectomy with clinical and pathologic risk factors associated with recurrence [1 –4]. Recently, the rates of mastectomy and contralateral prophylactic mastectomy for breast cancer have been on the rise for both early stage and locally advanced breast cancer [5–8]. This trend has been accompanied by an increase in immediate breast reconstruction (IBR), which has a number of p sycho...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: IMPT following IBR spared underlying organs and had low rates of acute toxicity. Reconstruction complications are more common in irradiated breasts, and reconstructive outcomes appear comparable with photon literature. Hypofractionation was associated with higher reconstruction failure rates. Further investigation of optimal dose-fractionation after IBR is needed. PMID: 31185327 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
University of Cincinnati researchers plan to enroll more than 20 women with early stage breast cancer in a unique clinical trial, which will involve the most expensive medical device in the region. The trial will involve proton radiotherapy designed to zap cancer with particles that travel faster than a bolt of lightning – and with great precision.  Treatment will take place at the $120 million Cincinnati Children’s Hospital Medical Center/UC Health Proton Therapy Center in Butler Coun ty,…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
University of Cincinnati researchers plan to enroll more than 20 women with early stage breast cancer in a unique clinical trial, which will involve the most expensive medical device in the region. The trial will involve proton radiotherapy designed to zap cancer with particles that travel faster than a bolt of lightning – and with great precision.  Treatment will take place at the $120 million Cincinnati Children’s Hospital Medical Center/UC Health Proton Therapy Center in Butler Coun ty,…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
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