Ferroptosis affects the progression of non-alcoholic steatohepatitis via the modulation of lipid peroxidation –mediated cell death in mice

Oxidative stress and its-associated lipid peroxidation play a key role in non-alcoholic steatohepatitis (NASH). Ferroptosis is a recently recognized type of cell death characterized by an iron dependent and lipid peroxidation –mediated non-apoptotic cell death. We demonstrate the impact of ferroptosis on the progression of NASH induced by methionine/choline-deficient diet (MCD) feeding for 10 days. RSL-3 (a ferroptosis inducer) treatment showed decreased hepatic expression of GPX4, and conversely increased 12/15-lipoxy genase, and apoptosis inducing factor, indicating that ferroptosis plays a key role in NASH-related lipid peroxidation and its-associated cell death.
Source: American Journal of Pathology - Category: Pathology Authors: Source Type: research