Mitochondria: sensors and mediators of innate immune receptor signaling.

Mitochondria: sensors and mediators of innate immune receptor signaling.
Curr Opin Microbiol. 2013 Jun 8;
Authors: Cloonan SM, Choi AM
Abstract
By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.
PMID: 23757367 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - June 8, 2013 Category: Microbiology Authors: Cloonan SM, Choi AM Tags: Curr Opin Microbiol Source Type: research