A new pimarane diterpenoid from the Botryotinia f.eliana fungus isolated from deep-sea water.

A new pimarane diterpenoid from the Botryotinia f.eliana fungus isolated from deep-sea water. Chem Biodivers. 2019 Oct 09;: Authors: Niu S, Peng G, Xia JM, Xie CL, Li Z, Yang XW Abstract A new pimarane diterpenoid, named botryopimarene A ( 1 ), was discovered from a fungus Botryotinia f.eliana MCCC 3A00494 isolated from the deep-sea water, together with ten known compounds. The planar structure of 1 was established based on the extensive spectroscopic analyses. The absolute configurations of tricyclic system in 1 were resolved by the theoretical ECD calculation, while the 15,16-diol moiety in the side chain was resolved by the Mo 2 (OAc) 4 -induced ECD spectrum. Compound 1 , featuring a Δ 9,11 double bond, was rarely discovered in pimarane family. Compounds 1-11 were tested their cytotoxic activities using six human cancer cell lines by the MTT method. However, none of the compounds exhibited detectable cytotoxicities (IC 50 > 20 μ M). PMID: 31596057 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research