Numerical study of the effect of vascular bed on heat transfer during high intensity focused ultrasound (HIFU) ablation of the liver tumor

In this study, the influence of vascular bed comprising terminal arterial branches on heat transfer in a liver tumor exposed to high intensity focused ultrasound (HIFU) is studied numerically. Also, the effect of vascular density on temperature distribution is investigated. A coupled set of acoustics, thermal, and fluid models is used to calculate the temperature distribution in the liver. The numerical model is established based on the Westervelt and bioheat equations along with the Navier-Stokes equations. Moreover, the acoustic streaming effect is included with Newtonian and non-Newtonian flow assumptions. It is found that in a vascular bed comprising terminal arterial branches, the effect of acoustic streaming is negligible because of the small diameter of these vessels, and the non-Newtonian behavior of blood flow reduces the peak streaming velocity. It is also shown that the vascular density (amount of tissue vascular content) has a considerable cooling effect on peak temperature and hence lesion volume in the liver and, by increasing the vascular density, the treatment duration is prolonged. Results show that when the tumor is embedded in the vascular bed, the cancer cells near the vessels walls remain viable. Some approaches are proposed and compared to improve the efficacy of HIFU in a tumor located in the vascular bed. These approaches include increasing the source pressure or transducer gain. It is concluded that for the assumed configuration of the vascular bed, a...
Source: Journal of Thermal Biology - Category: Biology Source Type: research

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Publication date: Available online 14 January 2020Source: Cancer GeneticsAuthor(s): Qian Nie, Gregory Omerza, Harshpreet Chandok, Matthew Prego, Meng-Chang Hsiao, Bridgette Meyers, Andrew Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Shannon Rowe, Jens Rueter, Honey V ReddiAbstractMolecular features of gynecologic cancers have been investigated in comprehensive studies, but correlation of these molecular signatures with clinical significance for precision medicine is yet to be established. Towards this end, we evaluated 95 gynecologic cancer cases submitted for testing...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Authors: Becker PS, Griffiths EA, Alwan LM, Bachiashvili K, Brown A, Cool R, Curtin P, Dinner S, Gojo I, Hicks A, Kallam A, Kidwai WZ, Kloth DD, Kraut EH, Landsburg D, Lyman GH, Miller R, Mukherjee S, Patel S, Perez LE, Poust A, Rampal R, Rosovsky R, Roy V, Rugo HS, Shayani S, Vasu S, Wadleigh M, Westbrook K, Westervelt P, Burns J, Keller J, Pluchino LA Abstract Management of febrile neutropenia (FN) is an integral part of supportive care for patients undergoing cancer treatment. The NCCN Guidelines for Hematopoietic Growth Factors provide suggestions for appropriate evaluation, risk determination, prophylaxis, and...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
More than three decades ago, when Tom Norris was fighting cancer, he underwent radiation therapy on his groin and his left hip. His cancer disappeared and hasn't come back. But Norris was left with a piercing ache that burned from his hip up his spine to his neck.Since then, Norris, now 70, has never had a single day free from pain. It cut short his career as an aircraft maintenance officer in the U.S. Air Force. It's been his constant companion, like the cane he uses to walk. On bad days, the pain is so excruciating, he's bedridden. Even on the best days, it severely limits his ability to move about, preventin...
Source: Psychology of Pain - Category: Anesthesiology Source Type: blogs
Is your alcohol use turning into something you are worried about? It can be hard for many people to determine whether or not they have a problem with alcohol, but chances are, you’re not happy with your current drinking habits. If you’re wondering “do I have an alcohol problem?’, keep reading for a few tell-tale signs, what is involved with treatment, and what can happen if you leave your alcohol problem untreated. Ask Yourself These Questions If you are asking yourself, “do I have an alcohol problem?”, as yourself the following questions first. If you answer yes to most or all of them,...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol detox alcohol treatment Source Type: blogs
Radiation therapy is an important technique to treat cancer. Due to the high occupational risks involved, the process is subject to severe safety regulations and standards. However, these standards do not mandate the usage of a particular hazard analysis m...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
On June 8, 2019, an article was published in the New York Times that clearly stated something I've been thinking about for quite some time. The article was titled, "The Business of Health Care Depends on Exploiting Doctors and Nurses" , and the subtitle was "One resource seems infinite and free: the professionalism of caregivers" . It was written by Dr. Danielle Ofri, a physician at Bellevue Hospital in New York City.The article outlines the ways in which healthcare providers are exploited for their compassion and dedication to patients in terms of being asked to see more patients and do more work than ...
Source: Digital Doorway - Category: Nursing Tags: burnout doctors family nurse practitioners hospitals medical care medical ethics nurses nursing Source Type: blogs
The dangers of alcohol begin at the first sip of the first drink. Although most responsible drinking habits shouldn’t be cause for major concern, everyone who drinks runs the risk of encountering the negative effects of alcohol. The Dietary Guidelines for Americans defines moderate drinking as up to 1 drink per day for women and up to 2 drinks per day for men.  A single drink is considered as: 12 ounces of beer (5% alcohol content) 8 ounces of malt liquor (7% alcohol content) 5 ounces of wine (12% alcohol content) 1.5 ounces of 80-proof (40% alcohol content) distilled spirits or liquor (e.g., gin, rum, vodka, ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Alcoholics Anonymous Source Type: blogs
This article lists 8 simple things we can do to help minimize anxiety during the holidays. Grounding Techniques for Holiday Gatherings: During the holiday season, even the most healthy individuals can become destabilized — when your internal sense of calm and confidence is unexpectedly thwarted. And if you struggle with mental health issues, your chances for destabilization increase even more. In this article, the author shares four simple ways we can ground ourselves when we’re feeling unhinged. Lonely, Burned-Out, and Depressed: The State of Millennials’ Mental Health Entering the 2020s: The mental heal...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Depression Disorders General Holiday Coping Mental Health and Wellness Psychology Around the Net Research Stress Body Dysmorphic Disorder grounding techniques Holiday Stress Holidays Millennials Pollution Se Source Type: blogs
From psychotherapy to physical therapy to immunotherapy, hundreds of treatment options are made feasible by modern medicine. Doctors sometimes find value in combining two or more treatment methods to better facilitate healing. Here's what to know about combination therapy and its application in wound care: "Combining methods can help combat the body's resistance to the treatment." Understanding combination therapy Combination therapy is when doctors treat diseases, injuries or other medical conditions with two or more drugs or therapies. The idea is that if one alone does not work, combining method...
Source: Advanced Tissue - Category: Dermatology Authors: Tags: Wound care products Source Type: news
CONCLUSIONS: Our PDX panel captures the molecular heterogeneity of glioblastoma and recapitulates many salient genetic and phenotypic features. All models and genomic data are openly available to investigators. PMID: 31852831 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
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