Improved characterisation of MRSA transmission using within-host bacterial sequence diversity

We examined the between-subject bottleneck, finding a wide range in the amount of diversity transmitted. Finally, we compared our approach to the simpler method of identifying transmission pairs using single nucleotide polymorphism (SNP) counts. This suggested that the optimum threshold for identifying a pair is 39 SNPs, if sensitivities and specificities are equally weighted.
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Source Type: research