Medical News Today: Indoor tanning and skin cancer risk across the years

Researchers looking at indoor tanning and cutaneous squamous cell carcinoma find that the overall number of tanning sessions links to increased risk.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Related Links:

Publication date: December 2019Source: Biomedicine &Pharmacotherapy, Volume 120Author(s): Li Tang, Yu-Ligh Liou, Zi-Rui Wan, Jie Tang, Yuan Zhou, Wei Zhuang, Guo WangAbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is a highly invasive malignant tumor and the majority of patients have advanced stage of ESCC at diagnosis with poor outcome. Identification of sensitive and specific biomarkers for early screening of ESCC is critical for improving patient overall survival.MethodsPyrosequencing was used to determine the magnitude of DNA methylation on the selected regions PAX1 (paired box gene1), SOX1(sex determin...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Objective Oral cancer ranks in the top three of all cancers in India, accounting for over 30% of all cancers reported. Elective neck dissection (END) is the mainstay of treatment in early disease. Performing ENDs for node negative (N0) patients can result in significant morbidity with questionable benefit and impair the patients’ quality of life. Sentinel Lymph Node Biopsy (SLNB), is an emerging investigation helping in risk stratification of patients with early oral cancer and node negative disease. SLNB is a simple, easy to perform investigation with a high sensitivity and plays a major role in avoiding neck diss...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Conclusions: This study successfully constructed a ceRNA network and a PPI network which play a crucial role in OSCC. A risk model was established to predict the prognosis, and four DERNAs are revealed with overall survival in patients with OSCC, suggesting that they may be potential biomarkers in tumor diagnosis and treatment.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: The results of the Keynote-048 study have already led to the approval of pembrolizumab in the first line for platin-sensitive HNSCC in the USA and the expected approval in Europe will presumably change the therapeutic landscape in the long term. In the future, effective therapies for patients without a response to programmed cell death 1 (PD-1)/PD-L1 inhibition will be needed. PMID: 31612261 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
AbstractObjectivesTo investigate the prognostic value of diffusion-weighted imaging (DWI) in predicting clinical outcome in patients with cervical cancer after concurrent chemoradiotherapy (CCRT).MethodsWe enrolled 124 cervical cancer patients who received definitive CCRT and underwent 3  T-MRI before and 1 month after initiating treatment. The mean apparent diffusion coefficient (ADC) value was measured on the tumor and the changes in ADC percentage (ΔADCmean) between the two time points were calculated. The Cox proportion hazard model was used to evaluate the associations between imaging or clinical varia...
Source: European Radiology - Category: Radiology Source Type: research
Cancers, Vol. 11, Pages 1583: CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation Cancers doi: 10.3390/cancers11101583 Authors: Seung-Phil Shin A-RA Goh Hyeon-Gu Kang Seok-Jun Kim Jong-Kwang Kim Kyung-Tae Kim John H Lee Yong-Soo Bae Yuh-Seog Jung Sang-Jin Lee The membrane glycoprotein CD200 binds to its receptor CD200R1 and induces tolerance, mainly in cells of the myeloid lineage; however, information regarding its role in solid tumors is limited. Here, we investigated whether CD200 expression, which is enri...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsCD137L mRNA was widely expressed in lung cancer cell lines whereas levels of protein expression were generally low. The low level of CD137L protein was still enough to induce T cells to produce IFN ‐γ that subsequently increased PD‐L1 expression. The CD137L‐induced negative immune regulation may represent a mechanism of immune escape.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsOur results indicate that high abundance of TIL-Bs and high density of direct B cell/CD8+ T cell interactions can predict patients with excellent prognosis, who would benefit from less invasive treatment. We propose that in extensively infiltrated tumors, TIL-Bs might recruit CD8+ T cells via CXCL9 and due to a highly activated phenotype contribute by secondary costimulation to the maintenance of CD8+ T cells in the tumor microenvironment.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Conditions:   Head and Neck Cancer;   Squamous Cell Carcinoma of Head and Neck Interventions:   Biological: pembrolizumab;   Biological: enoblituzumab;   Biological: MGA012;   Drug: Chemotherapeutic Combinations Sponsor:   MacroGenics Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Computed tomography (CT) is commonly used in all stages of oesophageal squamous cell carcinoma (SCC) management. Compared to basic CT features, CT radiomic features can objectively obtain more information abou...
Source: Cancer Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Health | Skin | Skin Cancer | Squamous Cell Carcinoma