Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia

We examined neuroimaging-derived hippocampal biomarkers in subjects at clinical high-risk (CHR) for psychosis to further characterize the pathophysiology of early psychosis. We hypothesized that glutamate hyperactivity reflected by increased metabolic activity derived from fMRI in the CA1 hippocampal subregion, and 1HMRS-derived hippocampal levels of GLX (glutamate/glutamine) represents early hippocampal dysfunction in CHR, and is predictive of conversion to syndromal psychosis.

Source: Biological Psychiatry - October 2, 2019 Category: Psychiatry Authors: Frank A. Provenzano, Jia Guo, Melanie M. Wall, Xinyang Feng, Hannah C. Sigmon, Gary Brucato, Michael B. First, Douglas L. Rothman, Ragy R. Girgis, Jeffrey A. Lieberman, Scott A. Small Tags: Archival Report Source Type: research