{alpha}v{beta}3-integrin regulates PD-L1 expression and is involved in cancer immune evasion [Microbiology]

Tumors utilize a number of effective strategies, including the programmed death 1/PD ligand 1 (PD-1/PD-L1) axis, to evade immune-mediated control of their growth. PD-L1 expression is mainly induced by IFN receptor signaling or constitutively induced. Integrins are an abundantly expressed class of proteins which play multiple deleterious roles in cancer...

Source: Proceedings of the National Academy of Sciences - September 30, 2019 Category: Science Authors: Andrea Vannini, Valerio Leoni, Catia Barboni, Mara Sanapo, Anna Zaghini, Paolo Malatesta, Gabriella Campadelli-Fiume, Tatiana Gianni Tags: PNAS Plus Source Type: research