A novel variant in SERPING1 gene causing angioedema in a patient with C1q low levels

Angioedema consists in a localized swelling of deep dermis, subcutaneous or submucosal tissues due to an extravasation of fluid into the interstitium. It could be divided into histaminergic angioedema, typically accompanied by pruritus and/or urticaria, and bradykinin angioedema. In bradykinin-mediated endotype, angioedema results from the generation of bradykinin, triggering an increase of vascular permeability. These forms are not associated with urticaria, do not respond to epinephrine, antihistamines or glucocorticoids and frequently affects the gastrointestinal mucosa1.

Source: Annals of Allergy, Asthma and Immunology - September 26, 2019 Category: Allergy & Immunology Authors: Mar ía-Alicia Calvo-Ferrer, Samuel Martín-Rodríguez, Nerea Ortega-Unanue, Ángel-Javier Blasco-Sarramián, Iván Bernardo-González Tags: Letters Source Type: research