Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets.

CONCLUSIONS: Increasing the affinity of rFVIIa to activated platelets resulted in approximately 50-fold increased potency both in vitro and in the mouse model. The correlation of in vivo with in vitro data using maximally activated platelets supports that these assay conditions are relevant when evaluating platelet-targeted haemostatic concepts.
PMID: 31549480 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - September 22, 2019 Category: Hematology Authors: Enoksson M, Martin EJ, Holmberg H, Jensen MS, Kjelgaard-Hansen M, Egebjerg T, Buchardt J, Krogh TN, Demuth H, Sanfridson A, Hilden I, Kjalke M, Brophy DF Tags: J Thromb Haemost Source Type: research