Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Nonerosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protocol

This study will evaluate in a large, independent, randomized controlled trial (RCT) the comparative effectiveness of a specific type of Chinese herbal granule with half-dose PPI and full-dose PPI in managing nonerosive reflux disease.Methods and analysisThis trial will be a multicenter, randomized, double-blind, placebo-controlled RCT. A total of 204 participants will be enrolled and randomized (1:1) to each group: herb granules plus 10 mg omeprazole plus 10 mg dummy omeprazole; and dummy herb granules plus 20 mg omeprazole. The efficacy measures will be the changes in scores in the Gastroesophageal Reflux Disease Questionnaire, the Short-Form 36, the Patient Report Outcome, the 17-item Hamilton Depression Scale, and the Signs and Symptoms Scale.DiscussionThis study will focus on the quality control of a Chinese medical formulation, and the RCT research procedure will be conducted under the supervision of the Good Clinical Practice (GCP) center. This trial will reduce the routine dosage of omeprazole while adding Jianpi Qinghua JQ granule, with the aim to discuss the safety and effectiveness of the Chinese herbal granule on esophageal and extraesophageal symptoms while meeting the ethical requirements.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research

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With all our talk of opiate withdrawal syndromes accompanied by nausea, headache, fatigue, and depression, it can be daunting, even terrifying, to people who face the prospect of tossing all wheat and grains into the trash bin, vowing to never let a Danish, donut, or dish of pasta cross your lips again. So it may help to lay out a timeline of what and when various changes can develop in the Wheat Belly wheat- and grain-free lifestyle. You can expect different symptoms and health conditions to recede at different rates, since they are caused by a variety of different mechanisms. For instance, the direct gastrointestinal tox...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle acid reflux detoxification grains IBS Inflammation joint pain opiates withdrawal Source Type: blogs
Abstract BackgroundFunctional dyspepsia (FD), a heterogeneous disorder, involves multiple pathogenetic mechanisms. Developing treatments for FD has been challenging. We performed a randomized, placebo‐controlled, double‐blind clinical trial to determine the efficacy of rikkunshito, a Japanese herbal medicine, in FD patients. MethodsFD patients (n = 192) who met the Rome III criteria without Helicobacter pylori infection, predominant heartburn, and depression were enrolled at 56 hospitals in Japan. After 2 weeks of single‐blind placebo treatment, 128 patients with continuous symptoms were randomly assig...
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Persisting gastroesophageal reflux disease (GERD) symptoms affect mental state and social activities and mental disorders likewise play a crucial role on GERD symptoms. The aim of this study was to analyze the data of Symptom Checklist by 90-Revised (SCL-90-R) questionnaire in patients with persisting GERD symptom and to explore the impact of psychological factors on them. The patients accepted SCL-90-R questionnaire survey, following endoscopy, high-resolution manometry (HRM) and ambulatory impedance-pH monitoring. Based on these results, we divided patients into different groups. The result of SCL-90-R was also compared...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research
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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement good habits good sleep health benefits of sleep pickthebrain sleep habit Source Type: blogs
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Diabetes Dr. Davis Grain Free Lifestyle Grains Inflammation News & Updates Wheat Belly Wheat Belly Total Health Wheat-Free Lifestyle Weight Loss Source Type: blogs
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle arthritis autoimmune diabetes eating disorder gluten grains Inflammation joint Weight Loss Source Type: blogs
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Source: NHS News Feed - Category: Consumer Health News Tags: Medication Neurology Older people Source Type: news
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories acid reflux allergy asthma cholesterol cramps gerd gluten grains heartburn IBS indigestion spastic colon Weight Loss Source Type: blogs
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