Efficacy and Safety of LC51-0255 in Subjects With Ulcerative Colitis

Condition:   Ulcerative Colitis Interventions:   Drug: LC51-0255;   Drug: Placebo Sponsor:   LG Chem Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conclusions: Anorectal function is impaired in IBD patients with perianal disease. Fecal incontinence correlates with poorer quality of life. Anorectal manometry and ultrasonography are useful tools for evaluating IBD patients. PMID: 31625422 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
Publication date: Available online 16 October 2019Source: International Journal of PharmaceuticsAuthor(s): Anastasia Foppoli, Alessandra Maroni, Saliha Moutaharrik, Alice Melocchi, Lucia Zema, Luca Palugan, Matteo Cerea, Andrea GazzanigaAbstract5-aminosalicylic acid (5-ASA) is the most widely used drug for the treatment of ulcerative colitis. The benefits of targeted delivery of 5-ASA to the large intestine are well known, resulting in reduced systemic absorption and increased local concentrations at the disease site. In the present study, a 5-ASA colon delivery system based on the time-dependent strategy, exploiting the r...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Condition:   Ulcerative Colitis Interventions:   Drug: GS-4875;   Drug: Placebo Sponsor:   Gilead Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ulcerative Colitis;   Artificial Intelligence;   Confocal Laser Endomicroscopy Intervention:   Diagnostic Test: The diagnosis of Artificial Intelligence and endoscopist Sponsor:   Shandong University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis Interventions:   Drug: GS-4875;   Drug: Placebo Sponsor:   Gilead Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ulcerative Colitis;   Artificial Intelligence;   Confocal Laser Endomicroscopy Intervention:   Diagnostic Test: The diagnosis of Artificial Intelligence and endoscopist Sponsor:   Shandong University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis Interventions:   Drug: GS-4875;   Drug: Placebo Sponsor:   Gilead Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Clinical / Medical
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Tim G.J. de Meij Endoscopic evaluation is mandatory in establishing the diagnosis of pediatric inflammatory bowel disease (IBD), but unfortunately carries a high burden on patients. Volatile organic compounds (VOC) have been proposed as alternative, noninvasive diagnostic biomarkers for IBD. The current study aimed to assess and compare the potential of fecal and urinary VOC as diagnostic biomarkers for pediatric IBD in an intention-to-diagnose cohort. In this cohort study, patients aged 4–17 years, referred to the outpatient clinic of a tertiary referral center under suspicion of IBD, were eligible to par...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionThese observations provide compelling evidence that BLFE could be considered as a viable natural strategy in the prevention and management of ulcerative colitis.Graphic abstract
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
More News: Inflammatory Bowel Disease | Research | Ulcerative Colitis