Development of Novel 3D Scaffolds Using BioExtruder by the Incorporation of Silica into Polycaprolactone Matrix for Bone Tissue Engineering

Publication date: Available online 18 September 2019Source: Materials Today CommunicationsAuthor(s): Nandini A. Pattanashetti, Sara Biscaia, Carla Moura, Geoffrey R. Mitchell, Mahadevappa Y. KariduraganavarAbstractDevelopment of three-dimensional (3D) scaffolds has acquired a great importance for bone repair and tissue reconstruction. Thus, this paper addresses the development of 3D scaffolds by varying the content of silicon dioxide (SiO2) in polycaprolactone (PCL) matrix. The scaffolds were fabricated by employing a novel fused deposition modelling technique (BioExtruder). The physicochemical properties of the developed 3D scaffolds were systematically studied using various techniques. The thermal properties and stability of the PCL and its composites were assessed using differential scanning calorimetry and thermogravimetric analysis. The morphology of the developed scaffolds was evaluated using scanning electron microscopy and optical microscopy, and found that the pore size was increased from 270 to 320 µm with increasing the SiO2 content in the PCL matrix. The wettability of the developed scaffolds was assessed using contact angle meter. The scaffold incorporating 15 weight% of SiO2 exhibited the highest hydrophilic property as well as thermal stability. The Young’s modulus value determined using universal testing machine indicated that the scaffold developed with 15 wt% of SiO2 exhibits 99.6 MPa. To assess the performance of the scaffol...
Source: Materials Today Communications - Category: Materials Science Source Type: research

Related Links:

In conclusion, the addition of triapine to cisplatin-radiotherapy improved the rate of metabolic complete response in patients with advanced-stage uterine cervix or vaginal cancers without significant toxicity. A phase III trial adequately powered to evaluate progression-free and overall survival is underway (NCT02466971).
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
We present a case of a 70-year-old woman with acute presentation of bilateral limb ischemia and abdominal pain. Angio-CT scan showed the sub-occlusion of the distal thoracic aorta due to a severe calcified coarctaction with intraluminal thrombosis, a chronic occlusion of the superior mesenteric and celiac trunk arteries, an hypertrophic inferior mesenteric artery associated with signs of partial left kidney ischemia.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
racias This paper addresses the problem of object recognition from colorless 3D point clouds inunderwater environments. It presents a performance comparison of state-of-the-art global descriptors,which are readily available as open source code. The studied methods are intended to assistAutonomous Underwater Vehicles (AUVs) in performing autonomous interventions in underwaterInspection, Maintenance and Repair (IMR) applications. A set of test objects were chosen as beingrepresentative of IMR applications whose shape is typically known a priori. As such, CAD modelswere used to create virtual views of the objects under re...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionAs PDH can lead to major and life threatening complications, it must remain in our minds as a possible cause of intestinal obstruction.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In this study, PGS elastomeric sheets were prepared by using a facile microwave method and used as elastomeric platform for the first time under mechanical stimulation to induct the tenocyte gene expression. It is revealed that elastomeric PGS sheets promote progenitor tendon cell structure by increasing proliferation and gene expression with regard to tendon extracellular matrix components. Human tenocytes were seeded onto poly(glycerol-sebacate) sheets and were cultured two days prior to transfer to dynamic culture in a bioreactor system. Cell culture studies were carried out for 12 days under 0%, 3% and 6% strain at 0.3...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 5 October 2019Source: International Journal of PharmaceuticsAuthor(s): Zhejie Chen, Yichen Hu, Jie Li, Chen Zhang, Fei Gao, Xuewei Ma, Jinming Zhang, Chaomei Fu, Funeng GengAbstractThe wound healing effects of pharmaceutic preparations of Periplaneta americana, Kangfuxin liquid, have been widely utilized in clinics. However, its wound repair efficacy is limited due to short retention capability on cutaneous wound location. Herein, Periplaneta americana extract (PAE), which showed pro-fibrogenic and pro-angiogeneic effects, was embedded into hydrogel film (PAE/Film) by solution cast method...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: The timing and the surgical method is not of major importance as far as growth outcomes (SNA and ANB) in UCLP are concerned. REGISTRATION: ISRCTN29932826. PROTOCOL: The protocol was not published before trial commencement. PMID: 31586198 [PubMed - as supplied by publisher]
Source: European Journal of Orthodontics - Category: Dentistry Authors: Tags: Eur J Orthod Source Type: research
CONCLUSIONS: There was no evidence of clinically significant differences in occlusion between the two surgical methods in each trial or between the trials. All mean scores showed more negative values in 8-year-olds compared with previously reported values in 5-year-olds. TRIAL REGISTRATION: ISRCTN29932826. PMID: 31586176 [PubMed - as supplied by publisher]
Source: European Journal of Orthodontics - Category: Dentistry Authors: Tags: Eur J Orthod Source Type: research
This study aimed to investigate a rabbit model of osteochondral regeneration using three-dimensional (3-D) printed polycaprolactone-hydroxyapatite (PCL-HA) scaffolds coated with umbilical cord blood mesenchymal stem cells (UCB-MSCs) and chondrocytes. MATERIAL AND METHODS Nine female New Zealand white rabbits were included in the study. The 3-D PCL-HA scaffolds were prepared using fused deposition modeling 3-D printing technology. Seeding cells were prepared by co-culture of rabbit UCB-MSCs and chondrocytes with a ratio of 3: 1. A total of 4×10⁶ cells were seeded on 3-D PCL-HA scaffolds and implanted into rabbits wi...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Cranial cruciate ligament (CCL) rupture is one of the most common causes of limb lameness in dogs. Surgical techniques based on tibial osteotomies such as tibial plateau leveling osteotomy and tibial tuberosit...
Source: Acta Veterinaria Scandinavica - Category: Veterinary Research Authors: Tags: Research Source Type: research
More News: Gastroschisis Repair | Materials Science | PET Scan | Toxicology