The effect of sacubitril/valsartan on the occurrence of ventricular arrhythmia and the risk of sudden cardiac death in patients with chronic heart failure with reduced left ventricular ejection fraction. Expert opinion of the Heart Rhythm and Heart Failure Associations of the Polish Cardiac Society.

The effect of sacubitril/valsartan on the occurrence of ventricular arrhythmia and the risk of sudden cardiac death in patients with chronic heart failure with reduced left ventricular ejection fraction. Expert opinion of the Heart Rhythm and Heart Failure Associations of the Polish Cardiac Society. Kardiol Pol. 2019 Sep 17;: Authors: Grabowski M, Ozierański K, Balsam P, Dąbrowski R, Farkowski MM, Gackowski A, Jędrzejczyk-Patej E, Kalarus Z, Leszek P, Nessler J, Sterliński M, Opolski G, Przybylski A Abstract Exacerbation of chronic heart failure (HF) is the most common cause of hospitalization in adults, which is associated with high morbidity and mortality, mainly in the mechanism of exacerbation of chronic HF or sudden cardiac death (SCD). A novelty in the treatment of HF with reduced left ventricular ejection fraction (HFrEF) in recent years has been registration of sacubitril/valsartan - a drug belonging to the angiotensin II receptor and neprilysin inhibitors (ARNI). Sacubitril/valsartan significantly reduces the severity of HF symptoms, the risk of hospitalization and death and is characterized by a good safety profile, due to which it has a strong position in the guidelines of international cardiac societies. However, the precise mechanism in which ARNI has a beneficial effect on cardiovascular mortality is not known. The advantages of ARNI are likely to result from improvement of left ventricle ejection fraction, reduced myocardial remodeling...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research

Related Links:

ConclusionExperiments show that the prognostic effect of the recurrent attention model is significantly higher than that of other traditional machine learning models. Because the model increases the attention mechanism, the important features affecting the prognostic results are obtained, which enables doctors to prescribe drugs according to the symptoms, take timely precautions and help patients to treat in time.Graphical abstract
Source: IRBM - Category: Biomedical Engineering Source Type: research
ConclusionsNMES is feasible in patients with AHF from immediately after admission.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Conclusion  Inhibition of SK channels was neither beneficial nor detrimental to ventricular arrhythmia development in the setting of AMI in this porcine model.
Source: Europace - Category: Cardiology Source Type: research
ConclusionsIn an analysis accounting for all active CIED ‐Ds, including those implanted during LVAD support, carrying such a device was associated with significantly better survival during LVAD support.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
AbstractSurgical treatment of cardiac fibroma is rare in patients with left ventricular noncompaction (LVNC). Although several case reports regarding cardiac fibroma have been published, resection in a patient with LVNC has not been described. Here, we describe the surgical treatment of left ventricular fibroma in a child with LVNC. We resected a cardiac fibroma in a 10 ‐year‐old boy with LVNC to control ventricular arrhythmia. Partial resection with careful tumor dissection was performed to avoid endocardial damage and entering the ventricular cavity. The postoperative course was uneventful, and the patient remains as...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
Conclusions: The clinical course of patients with ICM and DCM treated with CRT-D differs significantly during long-term follow-up, with increased mortality and incidence of ICD therapies in ICM patients. PMID: 31360179 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
ConclusionsThe incidence of arrhythmia and shock in patients with TTC does not correlate with the extent of myocardium involvement. The presence of LBBB in such cases can help recognize at-risk populations, and with timely intervention, life-threatening complications can be avoided. Despite limitations of the dataset and inability to establish causality, prospective studies with longer follow-up are warranted.
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
Authors: Wang Y, Po SS, Scherlag BJ, Yu L, Jiang H Abstract Introduction Cardiovascular diseases are accompanied by autonomic nervous system (ANS) imbalance which is characterized by decreased vagal tone. Preclinical and clinical studies have revealed that increasing vagal activity via vagus nerve stimulation (VNS) could protect the heart. Based on these studies, VNS has emerged as a potential non-pharmaceutical treatment strategy. Although it's still difficult to find the optimal stimulus parameters, however, in arrhythmia model, it is reported that low-level VNS (LL-VNS) exacts paradoxical effects from the high-l...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
AbstractIt is 35  years since the first description of arrhythmogenic right ventricular cardiomyopathy (ARVC) and more than 20 years since the first reports establishing desmosomal gene mutations as a major cause of the disease. Early advances in the understanding of the clinical, pathological and genetic archit ecture of ARVC resulted in consensus diagnostic criteria, which proved to be sensitive but not entirely specific for the disease. In more recent years, clinical and genetic data from families and the recognition of a much broader spectrum of structural disorders affecting both ventricles and associa t...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Consensus Document Source Type: research
ConclusionSGB increased cSNRT without changing heart rate. CSD was more beneficial for patients with mild ‐to‐moderate heart failure and faster VA.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
More News: Arrhythmia | Cardiology | Cardiovascular | Diovan | Heart | Heart Failure | Poland Health | Ventricular Arrhythmia