Immune protection provided by a precocious line trivalent vaccine against rabbit Eimeria

Publication date: Available online 20 September 2019Source: Veterinary ParasitologyAuthor(s): Sufang Fang, Xiaolong Gu, Saeed El-Ashram, Xiwang Li, Xiaojie Yu, Bing Guo, Huifeng Li, Nanxing Liu, Xianyong Liu, Ping Cui, Xun SuoAbstractA pilot study was conducted to evaluate the pathogenicity and immunogenicity of vaccinated rabbits with different doses of oocysts (5 × 102, 1 × 103, 1 × 104, and 5 × 104) of a precocious line, including Eimeria magna, E. intestinalis or E. media following the challenge with their corresponding parent strains. Our results showed that each precocious line had weak pathogenicity but good immunogenicity in terms of clinical symptoms, average daily weight gains (ADGs), and oocyst outputs. Therefore, a precocious line trivalent vaccine, including E. magna, E. intestinalis, and E. media was formulated. A total of sixty 40-day-old coccidia-free rabbits were allocated to ten treatments with a 2 × 3 factorial arrangement that included 2 vaccination doses (5 × 102 or 1 × 103 oocysts of the precocious line). Groups I to Ⅷ and Unimmunized Challenged Control group were challenged with mixed oocysts of their corresponding parent strains (1 × 104 oocysts of each parent strain) 14 days after vaccination. No clinical symptoms were observed in the immunized groups after vaccination. Average daily weight gains (ADGs) were similar to those of unimmunized unchallenged controls (P > 0.05) after vaccination or after challen...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research