Interferons: a molecular switch between damage and repair in ageing and Alzheimer’s disease
Publication date: Available online 18 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): N. Gorlé, R.E. VandenbrouckeAbstractAlzheimer’s disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer’s disease. This review focuses on how interferons affect the brain during ageing and whether they could be candidate therapeutic targets for the treatment of Alzheimer’s disease.
PMID: 32463103 [PubMed - in process]
PMID: 32463102 [PubMed - in process]
Publication date: June 2020Source: IJC Heart &Vasculature, Volume 28Author(s): Waqas Ullah, Yasar Sattar, Maryam Mukhtar, Hafez M. Abdullah, Vincent M. Figueredo, Donald C. Haas, David L. Fischman, M. Chadi Alraies
Publication date: Available online 28 May 2020Source: Stem Cell ResearchAuthor(s): Marga J. Bouma, Valeria Orlova, Francijna E. van den Hil, Hans-Jurgen Mager, Frank Baas, Peter de Knijff, Christine L. Mummery, Harald Mikkers, Christian Freund
AbstractThe driveline ’s durability is crucial for optimal long-term support with a left-ventricular assist device (LVAD). The incidence of percutaneous driveline fracture after HeartMate II LVAD implantation is low. For the first time, we describe a patient with an already repaired driveline and a massive constriction and twisting of the driveline in the area of the repair site. This dramatic finding necessitates a renewed exchange of the external part of the driveline by the manufacturer. Due to the increasing number of patients with elongated LVAD support, the stability of the driveline and possible repairs in clu...
CONCLUSIONS: Based on our experience the soft technique is a safe and feasible way to create a preperitoneal flap. Operating time is drastically reduced and the learning curve is reduced even for less experienced surgeons. PMID: 32456400 [PubMed - as supplied by publisher]
CONCLUSIONS: Our data show that a primary laparoscopic approach in patients with PPU is associated with postoperative advantages and acceptable rates of morbidity and mortality, essentially related to high Boey score. Therefore, we suggest that the surgical repair of PPU could be always started laparoscopically. PMID: 32456394 [PubMed - as supplied by publisher]
Publication date: 15 October 2020Source: Chemical Engineering Journal, Volume 398Author(s): Minhan Zou, Xin Zhao, Xiaoxuan Zhang, Yuanjin Zhao, Chunwu Zhang, Keqing Shi
Abstract Cotinine is the main metabolite of nicotine, which is metabolized in the liver through a cytochrome P450 enzyme. Different studies point to genetic instability caused by nicotine, such as single and double DNA strand breaks and micronuclei formation, but little is known about the effect of cotinine. Therefore, the present in vitro study assessed the effects of cotinine on cell viability and DNA damage in SH-SY5Y neuroblastoma cells, as well as genotoxicity related to oxidative stress mechanisms. Comparisons with nicotine were also performed. An alkaline comet assay modified by repair endonucleases (FPG, OGG1, and ...
Condition: Anterior Cruciate Ligament Injuries Interventions: Procedure: Immediate anterior cruciate ligament reconstruction; Other: Rehabilitation; Procedure: Optional delayed anterior cruciate ligament reconstruction Sponsors: Universitaire Ziekenhuizen Leuven; Federaal Kenniscentrum voor de Gezondheidszorg; Centre Hospitalier Universitaire de Liège Not yet recruiting